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MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the hemangioma animal model for differentiating infantile hemangioma from vascular malformation

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Author(s)
Chul-Ho SohnSeung Pyo ParkSeung Hong ChoiSung-Hye ParkSukwha KimLianji XuSang-Hyon KimJi An HurJaehoon ChoiTae Hyun Choi
Keimyung Author(s)
Kim, Sang HyonChoi, Jae Hoon
Department
Dept. of Internal Medicine (내과학)
Dept. of Plastic Surgery (성형외과학)
Journal Title
Nanomedicine
Issued Date
2015
Volume
11
Issue
1
Keyword
Iron oxide nanoparticleGLUT1Infantile hemangiomaMRI
Abstract
The purpose of this study is to evaluate the efficacy of glucose transporter protein 1 (GLUT1) antibody-conjugated iron oxide
nanoparticles (Fe3O4 NPs) as magnetic resonance imaging (MRI) molecular imaging agents for differentiating infantile hemangioma from
vascular malformation in the hemangioma animal model. The conjugation of Fe3O4 NPs with anti-GLUT1 antibodies leads to a significantly
increased uptake of NPs by human umbilical vein endothelial cells. MRI imaging following the intravenous injection of GLUT1 antibody-
Fe3O4 NPs yielded a significantly lower signal intensity than did unconjugated Fe3O4 NPs. Upon histological examination of the GLUT1
antibody-Fe3O4 NPs, Prussian blue-stained NPs were identified in CD31-positive endothelial cells of hemangioma. In contrast, when treated
with unconjugated Fe3O4 NPs, Prussian blue-stained NPs were found in macrophages rather than in endothelial cells. GLUT1 antibody
conjugation can effectively target the injected Fe3O4 NPs to GLUT1-positive tumor cells in infantile hemangioma.
From the Clinical Editor: This study evaluates the efficacy of glucose transporter protein 1 antibody-conjugated iron oxide nanoparticles as
MRI molecular imaging agents for differentiating infantile hemangioma from vascular malformation. Results demonstrate that CD-31
positive endothelial cells are targeted by this complex, which largely accumulates in macrophages resulting in significant MRI signal changes
compared to using iron oxide alone.
Key words: Iron oxide nanoparticle; GLUT1; Infantile hemangioma; MRI
Keimyung Author(s)(Kor)
김상현
최재훈
Publisher
School of Medicine
Citation
Chul-Ho Sohn et al. (2015). MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the hemangioma animal model for differentiating infantile hemangioma from vascular malformation. Nanomedicine, 11(1), 127–135. doi: 10.1016/j.nano.2014.08.003
Type
Article
ISSN
1549-9634
Source
https://www.sciencedirect.com/science/article/pii/S1549963414004262?via%3Dihub
DOI
10.1016/j.nano.2014.08.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33467
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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