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Comprehensive molecular characterization of gastric adenocarcinoma

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Author(s)
The Cancer Genome Atlas Research Network
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
Nature
Issued Date
2014
Volume
513
Issue
7517
Abstract
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been
complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of
295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular
classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent
PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and
PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours,which showelevatedmutation rates, includingmutations
of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the
diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and
tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine
kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine
Citation
The Cancer Genome Atlas Research Network. (2014). Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 513(7517), 202–209. doi: 10.1038/nature13480
Type
Article
ISSN
0028-0836
DOI
10.1038/nature13480
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33470
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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