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Invasive Candida Infections in Extremely Preterm Infants

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Author(s)
Chun Soo KimSang Lak Lee
Keimyung Author(s)
Kim, Chun SooLee, Sang Lak
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Neonatal Medicine
Issued Date
2013
Volume
20
Issue
3
Keyword
CandidaInfectionInfantsExtremely premature
Abstract
Invasive Candida infections (ICI) have become the third most common cause of late-onset infection among extremely preterm infants in the neonatal intensive care unit. Candida colonization of the skin and gastrointestinal tract is an important first step in the pathogenesis of invasive disease. Factors such as exposure to broad spectrum antimicrobials, especially third generation cephalosporin, parenteral nutrition including lipid emulsion, central venous catheter, and abdominal surgery increase the risk of invasive infection. A definite diagnosis of ICI requires isolation the organism from blood or other sterile body fluid. Thrombocytopenia is very common in neonatal candidiasis, but it is also often seen in babies with bacteremia. Candida is capable of invading all vital organs and following candidemia, therefore a thorough evaluation to rule out end organ dissemination is important. Amphotericin-B is the drug of choice for treating ICI. Antifungal susceptibility test is increasingly used to manage ICI, especially in situations refractory to initial antifugal therapy. Invasive candidiasis among extremely preterm infants is associated with chronic lung disease, severe retinopathy of prematurity, and neurodevelopmental impairment at infancy.
Keywords: Candida; Infection; Infants; Extremely premature
Alternative Title
극소 미숙아에서 침습 칸디다 감염
Keimyung Author(s)(Kor)
김천수
이상락
Publisher
School of Medicine
Citation
Chun Soo Kim and Sang Lak Lee. (2013). Invasive Candida Infections in Extremely Preterm Infants. Neonatal Medicine, 20(3), 367–374. doi: 10.5385/nm.2013.20.3.369
Type
Article
ISSN
2287-9412
DOI
10.5385/nm.2013.20.3.369
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33479
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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