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Surfactant Therapy in Severe Meconium Aspiration Syndrome

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Author(s)
Sang Lak LeeChun Soo Kim
Keimyung Author(s)
Lee, Sang LakKim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Neonatal Medicine
Issued Date
2013
Volume
20
Issue
3
Keyword
Meconium aspiration syndromePulmonary surfactant
Abstract
Meconium is a strong inactivator of pulmonary surfactant. The deficiency of
surfactant or surfactant dysfunction may contribute to respiratory failure in a
wide group of disorders, including meconium aspiration syndrome (MAS). We
reviewed the effect of pulmonary surfactant therapy for severe MAS in ours as well
as other countries. In general, surfactant therapy improves pulmonary oxygenation
(oxygenation index or arterial/alveolar oxygen tension) and reduces the requirement
for ventilation, and oxygen supplementation or hospitalization time. However,
its effects on mortality and pulmonary or extrapulmonary complications are
variable. In Korean studies, outborn infants are five times more common than
inborn infants; therefore, the initial hospital care at delivery including adequate
tracheal suctioning is important to improve the outcome of patients with severe
MAS. To confirm the effect of surfactant therapy in MAS, additional well-designed,
multicenter, randomized, controlled trials are needed. In addition, determining the
optimal type of surfactant therapy (bolus, lavage, or combined) and the appropriate
dose and duration of therapy is important.
Key Words: Meconium aspiration syndrome, Pulmonary surfactant
Alternative Title
중증 태변 흡인 증후군에서 폐표면 활성제 치료
Keimyung Author(s)(Kor)
이상락
김천수
Publisher
School of Medicine
Citation
Sang Lak Lee and Chun Soo Kim. (2013). Surfactant Therapy in Severe Meconium Aspiration Syndrome. Neonatal Medicine, 20(3), 318–322. doi: 10.5385/nm.2013.20.3.318
Type
Article
ISSN
2287-9412
DOI
10.5385/nm.2013.20.3.318
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33481
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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