계명대학교 의학도서관 Repository

Alzheimer’s disease and Parkinson’s disease genome-wide association study top hits and risk of Parkinson’s disease in Korean population

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Author(s)
Sun Ju ChungYusun JungMyunghee HongMi Jung KimSooyeoun YouYoung Jin KimJuyeon KimKyuyoung Song
Keimyung Author(s)
You, Soo Yeoun
Department
Dept. of Neurology (신경과학)
Journal Title
Neurobiology of Aging
Issued Date
2013
Volume
34
Issue
11
Keyword
Parkinson’s diseaseAlzheimer’s diseaseSingle nucleotide polymorphismGenetic associationSNCA
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) have overlapping clinical and pathological features, suggesting a common pathway for these 2 neurodegenerative disorders. Here we investigated the association of both AD and PD GWAS top hits with PD susceptibility. We selected 25 single nucleotide polymorphisms (SNPs) in 9 genes (ABCA7, APOE, BST1, CLU, CR1, LRRK2, PARK16, PICALM, and SNCA) that were genotyped in 1036 PD case patients and 1208 controls. Case patients and controls were all ethnic Koreans. Logistic regression analysis was performed to calculate age- and sex-adjusted odds ratios. None of the AD-susceptibility loci (ABCA7, APOE, CLU, CR1, and PICALM) showed statistically significant association with PD susceptibility. In contrast, we replicated associations of SNCA, LRRK2, BST1, and PARK16 with PD susceptibility in Koreans. Of those, the SNCA SNP rs11931074 showed the most significant association with PD susceptibility (adjusted odds ratio = 1.48; 95% confidence interval = 1.31–1.67; p = 2.20E-10). In a logistic regression analysis with SNPs coded under an additive model, there was no significant genetic interaction between the LRRK2 and the PARK16 locus gene RAB7L1 in PD risk. Our results confirm the associations of SNCA, LRRK2, BST1, and PARK16 with PD susceptibility and fail to show significant associations of AD genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population.
Keywords
Parkinson's disease;
Alzheimer's disease;
Single nucleotide polymorphism;
Genetic association;
SNCA
Keimyung Author(s)(Kor)
유수연
Publisher
School of Medicine
Citation
Sun Ju Chung et al. (2013). Alzheimer’s disease and Parkinson’s disease genome-wide association study top hits and risk of Parkinson’s disease in Korean population. Neurobiology of Aging, 34(11), 2695.e1–2695.e7-2695.e1–2695.e7. doi: 10.1016/j.neurobiolaging.2013.05.022
Type
Article
ISSN
0197-4580
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0197458013002352?via%3Dihub
DOI
10.1016/j.neurobiolaging.2013.05.022
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33489
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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