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Cerebral perfusion abnormality in narcolepsy with cataplexy

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Author(s)
Eun Yeon JooSeung Bong HongWoo Suk TaeJee Hyun KimSun Jung HanYong Won ChoChang Ho YoonSung Ik LeeMann Hyung LeeKyung Han LeeMyoung-Hee KimByung Tae KimLeen Kim
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Neuroimage
Issued Date
2005
Volume
28
Issue
2
Keyword
Narcolepsy99mTc-ethylcysteinate dimer (ECD)SPECTHypothalamusCerebral perfusion
Abstract
To investigate abnormal cerebral perfusion in narcoleptics with cataplexy, 25 narcoleptics with cataplexy and 25 normal controls were enrolled in this study. Cerebral perfusion was measured by brain single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer. Patients and normal controls had not received any medication prior to the SPECT scan. Differences in cerebral perfusion between narcoleptics and normal controls were subjected to statistical parametric mapping (SPM) analysis. Overnight polysomnography and multiple sleep latency test (MSLT) were performed in all patients. Brain SPECT was carried out on all patients and normal controls during the waking state. Clinical symptoms and MSLT results of all patients are in accord with the International Classification of Sleep Disorders criteria for narcolepsy. MSLT showed a short mean sleep latency (1.69 ± 1.0 min) and 2–5 sleep onset REM periods in individual patient. SPM analysis of brain SPECT showed hypoperfusion of the bilateral anterior hypothalami, caudate nuclei, and pulvinar nuclei of thalami, parts of the dorsolateral/ventromedial prefrontal cortices, parahippocampal gyri, and cingulate gyri in narcoleptics [P < 0.05 by Student's t test with false discovery rate (FDR) correction]. Significant hypoperfusion in the white matter of frontal and parietal lobes was also noted in narcoleptics. This study shows reduced cerebral perfusion in subcortical structures and cortical areas in narcoleptics. The distribution of abnormal cerebral perfusion is concordant with the pathway of the cerebral hypocretin system and may explain the characteristic features of narcolepsy, i.e., cataplexy, emotional lability, and attention deficit.

Keywords
Narcolepsy;
Cerebral perfusion;
99mTc-ethylcysteinate dimer (ECD);
SPECT;
Hypothalamus
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Eun Yeon Joo et al. (2005). Cerebral perfusion abnormality in narcolepsy with cataplexy. Neuroimage, 28(2), 410–416. doi: 10.1016/j.neuroimage.2005.06.019
Type
Article
ISSN
1053-8119
Source
https://www.sciencedirect.com/science/article/pii/S1053811905004271?via%3Dihub
DOI
10.1016/j.neuroimage.2005.06.019
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33496
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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