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Altered white matter integrity in primary restless legs syndrome patients: diffusion tensor imaging study

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Author(s)
Yongmin ChangJong Soo PaikHui Joong LeeHyuk Won ChangHye-Jin MoonRichard P. AllenChristopher J. EarleyYong Won Cho
Keimyung Author(s)
Moon, Hye JinCho, Yong WonChang, Hyuk Won
Department
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Journal Title
Neurological Research
Issued Date
2014
Volume
36
Issue
8
Abstract
Objectives: A prior diffusion tensor imaging (DTI) of restless legs syndrome (RLS) subjects found alterations in brain white matter (WM). The aim of this study was to explore the possible mechanism of altered integrity of brain WM in RLS patients.
Methods: The DTI measurement was performed in 22 subjects with RLS and 22 age-matched control subjects. Using a voxel-based analysis, fractional anisotropy (FA) and axial and radial diffusivities (AD and RD) were compared between RLS and control subjects with a two-sample t-test, and correlation analysis was performed in RLS subjects.
Results: RLS subjects demonstrated decreased FA in the genu of the corpus callosum and frontal WM adjacent to the inferior frontal gyrus compared with the control subjects. For areas of decreased FA, both the AD and RD were higher than that in the control subjects.
Discussion: Our findings suggest that loss of axonal density and myelin may account for WM changes seen in a prior study of RLS subjects.
Keywords: Diffusion tensor imaging; Myelin; Restless legs syndrome; Statistical parametric mapping; White matter.
Keimyung Author(s)(Kor)
문혜진
조용원
장혁원
Publisher
School of Medicine
Citation
Yongmin Chang et al. (2014). Altered white matter integrity in primary restless legs syndrome patients: diffusion tensor imaging study. Neurological Research, 36(8), 769–774. doi: 10.1179/1743132814Y.0000000336
Type
Article
ISSN
0161-6412
Source
https://www.tandfonline.com/doi/full/10.1179/1743132814Y.0000000336
DOI
10.1179/1743132814Y.0000000336
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33501
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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