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Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats

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Author(s)
Seong-Ryong LeeJae-Kyu Cheun
Keimyung Author(s)
Cheun, Jae KyuLee, Seong Ryong
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Dept. of Pharmacology (약리학)
Journal Title
Neurological Research
Issued Date
1999
Volume
21
Issue
2
Keyword
Propofolkainic acidexcitotoxicityneuroprotection
Abstract
The goal of this study was to determine whether propofol has protective effect against kainic acid (KA)-induced excitotoxicity. Administration of propofol (25 mg kg-1 i.p.) was done 2 h before KA (10 mg kg-1 i.p.), immediately after, and 2 h, 4 h, 6 h, and 12 h after the KA, and twice daily for an additional three days. Neuronal cell death in CA1 and CA3 subsector of hippocampus was evaluated quantitatively four days after KA. The KA and propofol-injected rats had a greater number of surviving neuronal cells than did KA (and vehicle)-injected rats. Our results suggest that propofol holds potential for the protection of neuronal cells against KA induced excitotoxicity.
Keimyung Author(s)(Kor)
전재규
이성용
Publisher
School of Medicine
Citation
Seong-Ryong Lee and Jae-Kyu Cheun. (1999). Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats. Neurological Research, 21(2), 225–228.
Type
Article
ISSN
0161-6412
Source
https://www.tandfonline.com/doi/abs/10.1080/01616412.1999.11740922
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33503
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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