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Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia: 15O-water positron emission tomography

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Author(s)
Jeong-Ho SeokHae-Jeong ParkJong-Doo LeeHye-Sun KimJi-Won ChunSang Joon SonMaeng-Keun OhJeonghun KuHyeongrae LeeJae-Jin Kim
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Psychiatry and clinical neurosciences
Issued Date
2012
Volume
66
Issue
7
Keyword
major depressive disorderpositron emission tomographyschizophreniasustained attention
Abstract
Aim: Attention deficit has been reported in both
schizophrenia patients and patients with major
depressive disorder (MDD). The aim of this study was
to elucidate the deficits in sustained attention and
associated neural network dysfunctions in schizophrenia
patients and MDD patients, and to investigate
the difference between the two patient groups.
Methods: Twelve schizophrenia patients, 12 patients
with non-psychotic MDD, and 12 healthy control
subjects participated in this study. A sustained attention
to response task (SART) was used to measure
attention capacity. Cerebral blood flow (CBF) during
attention tasks was measured using H2
15O positron
emission tomography. Statistical parametric mapping
and analysis of covariance were performed to
compare the behavioral performance and CBF
changes during SART among three groups.
Results: Behavioral performances were not significantly
different among the three groups except for an
increased commission error rate in the schizophrenia
group. Regional CBF during SART was significantly
reduced in the left inferior frontal gyrus, the left
cuneus, and the right superior parietal lobule and
increased in the right superior frontal gyrus and the
right cuneus in the schizophrenia group compared to
the healthy control group. In the MDD group, neither
significant regional CBF difference nor behavioral
deficit was found compared to the healthy control
group.
Conclusion: Behavioral performance deficit and perfusion
changes in the prefrontal and parietal cortices
during SART were observed only in the schizophrenia
group. Prefrontal and parietal network dysfunction
for sustained attention may be involved in the pathophysiology
of schizophrenia.
Key words: major depressive disorder, positron
emission tomography, schizophrenia, sustained
attention.
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Jeong-Ho Seok et al. (2012). Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia: 15O-water positron emission tomography. Psychiatry and clinical neurosciences, 66(7), 564–572. doi: 10.1111/j.1440-1819.2012.02407.x
Type
Article
ISSN
1323-1316
DOI
10.1111/j.1440-1819.2012.02407.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33512
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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