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Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death

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Author(s)
Beom Joon KimSeung-Hoon LeeKeun-Hwa JungKyung-Ho YuByung-Chul LeeJae-Kyu Roh
Keimyung Author(s)
Sohn, Sung Il
Department
Dept. of Neurology (신경과학)
Journal Title
Neurology
Issued Date
2012
Volume
79
Issue
9
Abstract
Objective: Paradoxical longevity in obese patients with established disease has been documented
in various conditions. We aimed to find whether such a relationship exists in ischemic stroke
patients, with stratified analyses according to time of death after stroke, age, and cause of death.
Methods: The Korean Stroke Registry (KSR) is a nationwide, multicenter, prospective registry of
acute stroke. For 7.5 years, data on 34,132 patients with acute ischemic stroke were collected
through KSR, and their mortality information was ascertained through a governmental statistical
office. We assessed relative hazard of mortality according to obesity status.
Results: Stroke survivors whose body mass index (BMI) values were lower than the chosen reference
level of 20–23 had increased risks of long-term mortality (hazard ratio [HR] of 1.36 and
95% confidence interval [CI] of 1.25–1.48 for BMI 18.5; HR of 1.14 and 95% CI of 1.03–1.26
for BMI 18.5–20), whereas obese stroke patients had decreased risks of mortality (HR of 0.83
and 95% CI of 0.74–0.92 for BMI 27.5–30; HR of 0.77 and 95% CI of 0.63–0.93 for BMI
30–32.5). Inverse association between obesity status and mortality was not evident until 90
days after stroke but became significant 1 year after onset of stroke. Such an association was
more prominent in stroke patients who were less than 65 years old, but it remained constant in all
age groups. The paradoxical relationship remained significant, regardless of causes of death.
Conclusions: Our results documented obesity paradox in stroke survivors, regardless of age and
causes of death, and it became evident a sufficient time after stroke onset. N
Keimyung Author(s)(Kor)
손성일
Publisher
School of Medicine
Citation
Beom Joon Kim et al. (2012). Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death. Neurology, 79(9), 856–863.
Type
Article
ISSN
0028-3878
Source
http://n.neurology.org/content/79/9/856.long
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33514
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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