Material-Specific Memory in Temporal Lobe Epilepsy: Effects of Seizure Laterality and Language Dominance

Abstract

This study investigated the effects of seizure laterality and language dominance on materialspecific memory in temporal lobe epilepsy (TLE). Left TLE (LTLE) patients with lefthemisphere language dominance (LHLD) showed significantly higher nonverbal than verbal memory capacity, whereas right TLE patients with LHLD showed significantly better verbal than nonverbal memory capacity. LTLE patients with non-left-hemisphere language dominance (NLHLD) showed significantly better verbal memory capacity compared with LTLE patients with LHLD. Thus, selective verbal or nonverbal memory deficits that are dependent on side of seizure onset were apparent in patients with LHLD but not in patients with NLHLD. Relative sparing of verbal memory capacity in LTLE patients with NLHLD may reflect interhemispheric reorganization of verbal memory function.