계명대학교 의학도서관 Repository

Cytokine imbalance in the pathophysiology of major depressive disorder

Metadata Downloads
Author(s)
Yong-Ku KimKyeong-Sae NaKyung-Ho ShinHan-Yong JungSo-Hyun ChoiJung-Bum Kim
Keimyung Author(s)
Kim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Issued Date
2007
Volume
31
Issue
5
Keyword
AntidepressantsCytokinesInterleukinsInterferonsPsychoimmunologyTransforming growth factors
Abstract
Objective: A substantial body of evidence indicates that dysregulation of the immune system is associated with Major Depressive Disorder
(MDD). Because most cytokines have pleiotropic effects, we measured various subsets of cytokines to examine the association between immune
response and MDD.
Methods: Forty-eight hospitalized MDD patients and 63 normal controls were recruited. We measured in vitro monocytic (IL-6 and tumor necrosis
factor (TNF)-alpha), Th1 (interferon (IFN)-gamma and interleukin (IL)-2), Th2 (IL-4), and Treg (transforming growth factor (TGF)-beta1)
cytokine production as well as IL-2/IL-4 and IFN-gamma/IL-4 ratios for both groups. Depressive symptoms were assessed by Hamilton
Depression Rating Scale. Patients were evaluated before and after 6 weeks of antidepressant treatment.
Results: At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher, whereas IFN-gamma, IL-2,
and IL-4 were significantly lower in MDD patients. After treatment, IL-6 and TGF-beta1 production were significantly lower than before
treatment.
Conclusion: We suggest that activation of monocytic proinflammatory cytokines, and inhibition of both Th1 and Th2 cytokines may be associated
with immunological dysregulation in MDD. TGF-beta1 may be associated with the regulation of monocytic cytokines as well as Th1 and Th2
cytokines in MDD.
© 2007 Elsevier Inc. All rights reserved.
Keywords: Antidepressants; Cytokines; Interleukins; Interferons; Psychoimmunology; Transforming growth factors
Keimyung Author(s)(Kor)
김정범
Publisher
School of Medicine
Citation
Yong-Ku Kim et al. (2007). Cytokine imbalance in the pathophysiology of major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(5), 1044–1053. doi: 10.1016/j.pnpbp.2007.03.004
Type
Article
ISSN
0278-5846
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S027858460700098X?via%3Dihub
DOI
10.1016/j.pnpbp.2007.03.004
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33530
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.