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Endothelin-induced changes in intracellular calcium in human microglia

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Author(s)
J.G. McLarnonX. WangJ.H. BaeS.U. Kim
Keimyung Author(s)
Bae, Jae Hoon
Department
Dept. of Physiology (생리학)
Journal Title
Neuroscience Letters
Issued Date
1999
Volume
263
Issue
1
Keyword
Human microgliaIntracellular calciumCalcium influxEndothelinETB receptors
Abstract
Calcium-sensitive spectrofluorometry was used to study the effects of endothelin on levels of intracellular calcium [Ca2+]i in cultured human microglia. Both ET-1 and ET-3 induced transient, non-desensitizing, increases in [Ca2+]i in over 80% of the cells studied. The responses to either ET-1 or ET-3 were significantly diminished in amplitude and duration in Ca2+-free solution suggesting a prominent contribution of Ca2+ influx to the response. ET-1 induced changes in [Ca2+]i were not altered in the presence of the selective ETA antagonist BQ610 but were significantly reduced with the selective ETB antagonist BQ780. These results confirm the expression of ETB receptors on human microglia, these receptors may serve a role in a signaling pathway between microglia and endothelial cells.

Keywords
Human microglia;
Intracellular calcium;
Calcium influx;
Endothelin;
ETB receptors
Keimyung Author(s)(Kor)
배재훈
Publisher
School of Medicine
Citation
J.G. McLarnon et al. (1999). Endothelin-induced changes in intracellular calcium in human microglia. Neuroscience Letters, 263(1), 9–12. doi: 10.1016/S0304-3940(99)00082-8
Type
Article
ISSN
0304-3940
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304394099000828?via%3Dihub
DOI
10.1016/S0304-3940(99)00082-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33545
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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