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Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus

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Author(s)
Hyeon-Ju KimKwang-Deog MoonSang-Young OhSang-Pyo KimSeong-Ryong Lee
Keimyung Author(s)
Kim, Sang PyoLee, Seong Ryong
Department
Dept. of Pathology (병리학)
Dept. of Pharmacology (약리학)
Brain Research Institute (뇌연구소)
Journal Title
Neuroscience Letters
Issued Date
2001
Volume
314
Issue
issues 1-2
Keyword
Gastrodia elataKainic acidExcitotoxicitySeizureHippocampusNeuroprotection
Abstract
Gastrodia elata (GE) has been used traditionally for the treatment of convulsive diseases such as epilepsy in oriental countries including South Korea and still occupies an important place in traditional medicine in Asia. We studied the anticonvulsive effect and protective effect of the ether fraction of methanol extracts (EFME) of GE against hippocampal neuronal damage after kainic acid administration in mice. Mice were treated with the EFME of GE (200 or 500 mg/kg per day, p.o.) for 14 days before kainic acid injection (45 mg/kg, i.p.). The EFME of GE (at the dose of 500 mg/kg) delayed the onset time of neurobehavioral change (P<0.01) and reduced the severity of convulsions (P<0.05) and hippocampal neuronal damage in the CA1 (P<0.01) and CA3 (P<0.05) regions. Our results show that The EFME of GE has anticonvulsive effect and putative neuroprotective effect against excitotoxicity induced by kainic acid.

Keywords
Gastrodia elata;
Kainic acid;
Excitotoxicity;
Seizure;
Hippocampus;
Neuroprotection
Keimyung Author(s)(Kor)
김상표
이성용
Publisher
School of Medicine
Citation
Hyeon-Ju Kim et al. (2001). Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neuroscience Letters, 314(issues 1-2), 65–68. doi: 10.1016/S0304-3940(01)02296-0
Type
Article
ISSN
0304-3940
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304394001022960?via%3Dihub
DOI
10.1016/S0304-3940(01)02296-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33546
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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