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Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa

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Author(s)
Kyung Ran KimJeonghun KuJung-Hyun LeeHyeongrae LeeYoung-Chul Jung
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Neuroscience Letters
Issued Date
2012
Volume
521
Issue
2
Keyword
Anorexia nervosaBulimia nervosaAnterior insulaFunctional connectivityEffective connectivity
Abstract
The anterior insula has been proposed to play a crucial role in eating disorders. However, it is still poorly understood how the anterior insula is involved in anorexia nervosa (AN) and bulimia nervosa (BN), which are characterized by opposite motivational responses to food. We applied a cue-reactivity paradigm using blood oxygen level-dependent functional magnetic resonance imaging in women with AN (N = 18) and BN (N = 20) and age-matched healthy controls (N = 20). We defined the left anterior insula as a region-of-interest and performed seed-based functional connectivity and effective connectivity MRI analysis. In response to food images compared to non-food images, both the AN group and BN group demonstrated increased activity in the left anterior insula. In the AN group, the left anterior insula demonstrated significant interactions with the right insula and right inferior frontal gyrus. In the BN group, the left anterior insula demonstrated significant interactions with the medial orbitofrontal cortex. The distinct patterns of functional and effective connectivity of the anterior insula may contribute to the different clinical features of AN and BN.



Highlights


► Functional and effective connectivity of the insula in women with eating disorders was analyzed. ► Anorexia nervosa demostrated synchrony between the insula and the right inferior frontal cortex. ► Bulimia nervosa demonstrated synchrony between the insula and the medial orbitofrontal cortex.

Keywords
Anorexia nervosa;
Bulimia nervosa;
Anterior insula;
Functional connectivity;
Effective connectivity
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Kyung Ran Kim et al. (2012). Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa. Neuroscience Letters, 521(2), 152–157. doi: 10.1016/j.neulet.2012.05.075
Type
Article
ISSN
0304-3940
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304394012007732?via%3Dihub
DOI
10.1016/j.neulet.2012.05.075
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33547
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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