Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils
- Affiliated Author(s)
- 이성용; 김상표; 김지언
- Alternative Author(s)
- Lee, Seong Ryong; Kim, Sang Pyo; Kim, Ji Eun
- Journal Title
- Neuroscience Letters
- ISSN
- 0304-3940
- Issued Date
- 2000
- Keyword
- Global ischemia; Gerbil; Hippocampus; Neuroprotection; Antiepileptic; Topiramate
- Abstract
- The purpose of this study was to examine whether topiramate would reduce neuronal damage after transient global ischemia in the gerbils because topiramate blocks voltage sensitive sodium channels and non-N-methyl-d-aspartate receptors and enhances γ-aminobutyric acid-mediated inhibitory transmission. Both common carotid arteries were occluded for 3 min with microaneurysmal clips. The gerbils were treated with topiramate (50, 100, or 200 mg/kg, i.p.) immediately after ischemia. Neuronal cell damage in the hippocampal CA1 region was evaluated quantitatively 7 days after ischemia. Topiramate at the dose of 50 mg/kg failed to reduce hippocampal neuronal damage. However, topiramate when administered at the dose of 100 or 200 mg/kg significantly reduced hippocampal neuronal damage in dose-dependent manner (P<0.001 and P<0.0005, respectively). These results suggest that topiramate has a neuroprotective effect against neuronal damage following global ischemia in the gerbils.
Keywords
Global ischemia;
Gerbil;
Hippocampus;
Neuroprotection;
Antiepileptic;
Topiramate
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