계명대학교 의학도서관 Repository

Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils

Metadata Downloads
Author(s)
Seong-Ryong LeeSang-Pyo KimJi-Eun Kim
Keimyung Author(s)
Lee, Seong RyongKim, Sang PyoKim, Ji Eun
Department
Dept. of Pharmacology (약리학)
Dept. of Pathology (병리학)
Dept. of Neurology (신경과학)
Journal Title
Neuroscience Letters
Issued Date
2000
Volume
281
Issue
Issues 2-3
Keyword
Global ischemiaGerbilHippocampusNeuroprotectionAntiepilepticTopiramate
Abstract
The purpose of this study was to examine whether topiramate would reduce neuronal damage after transient global ischemia in the gerbils because topiramate blocks voltage sensitive sodium channels and non-N-methyl-d-aspartate receptors and enhances γ-aminobutyric acid-mediated inhibitory transmission. Both common carotid arteries were occluded for 3 min with microaneurysmal clips. The gerbils were treated with topiramate (50, 100, or 200 mg/kg, i.p.) immediately after ischemia. Neuronal cell damage in the hippocampal CA1 region was evaluated quantitatively 7 days after ischemia. Topiramate at the dose of 50 mg/kg failed to reduce hippocampal neuronal damage. However, topiramate when administered at the dose of 100 or 200 mg/kg significantly reduced hippocampal neuronal damage in dose-dependent manner (P<0.001 and P<0.0005, respectively). These results suggest that topiramate has a neuroprotective effect against neuronal damage following global ischemia in the gerbils.

Keywords
Global ischemia;
Gerbil;
Hippocampus;
Neuroprotection;
Antiepileptic;
Topiramate
Keimyung Author(s)(Kor)
이성용
김상표
김지언
Publisher
School of Medicine
Citation
Seong-Ryong Lee et al. (2000). Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils. Neuroscience Letters, 281(Issues 2-3), 183–186. doi: 10.1016/S0304-3940(00)00847-8
Type
Article
ISSN
0304-3940
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304394000008478?via%3Dihub
DOI
10.1016/S0304-3940(00)00847-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33550
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.