계명대학교 의학도서관 Repository

Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

Metadata Downloads
Author(s)
Seong-Ryong LeeSeong-Il SuhSang-Pyo Kim
Keimyung Author(s)
Lee, Seong RyongSuh, Seong IlKim, Sang Pyo
Department
Dept. of Pharmacology (약리학)
Dept. of Microbiology (미생물학)
Dept. of Pathology (병리학)
Journal Title
Neuroscience Letters
Issued Date
2000
Volume
287
Issue
3
Keyword
Global ischemiaGerbilHippocampusNeuroprotectionGreen teaPolyphenol(−)-Epigallocatechin gallateAntioxidant
Abstract
Recent studies have shown that green tea polyphenols reduce free radical-induced lipid peroxidation. Oxygen free radical injury plays an important role in neuronal damage induced by brain ischemia and reperfusion. The purpose of this study was to examine whether (−)-epigallocatechin gallate (EGCG) would reduce neuronal damage after transient global ischemia in the gerbils because EGCG has a potent antioxidant property as a green tea polyphenol. To produce transient global ischemia, both common carotid arteries were occluded for 3 min with microaneurysmal clips. The gerbils were treated with EGCG (10, 25, or 50 mg/kg, i.p.) immediately after ischemia. Neuronal cell damage in the hippocampal CA1 region was evaluated quantitatively 5 days after ischemia by a blinded investigator. EGCG at the dose of 10 mg/kg failed to reduce hippocampal neuronal damage. However, EGCG when administered at the dose of 25 or 50 mg/kg significantly reduced hippocampal neuronal damage in a dose-dependent manner (P<0.001, respectively). The present results show that the green tea polyphenol, EGCG, has a neuroprotective effect against neuronal damage following global ischemia in the gerbils.

Keywords
Global ischemia;
Gerbil;
Hippocampus;
Neuroprotection;
Green tea;
Polyphenol;
(−)-Epigallocatechin gallate;
Antioxidant
Keimyung Author(s)(Kor)
이성용
서성일
김상표
Publisher
School of Medicine
Citation
Seong-Ryong Lee et al. (2000). Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neuroscience Letters, 287(3), 191–194. doi: 10.1016/S0304-3940(00)01159-9
Type
Article
ISSN
0304-3940
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304394000011599?via%3Dihub
DOI
10.1016/S0304-3940(00)01159-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33551
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.