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Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy

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Author(s)
Yongmin ChangSeung-Tae WooJae-Jun LeeHui-Jin SongHui Joong LeeDon-Sik YooSuk Hwan KimHun LeeYoung Joo KwonHyung Jin AhnJoon-Ho AhnSin-Jae ParkYoung Cheol WeongIn-Sung ChungKyoung Sook JeongYangho Kim
Keimyung Author(s)
Chung, In Sung
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
NeuroToxicology
Issued Date
2009
Volume
30
Issue
6
Keyword
Manganese (Mn)Magnetic resonance spectroscopy (MRS)WelderGlial cellNeurotoxinNeuropsychologicalImagingNeurobehavioralNeurodegeneration
Abstract
Background

Occupational and environmental exposure to manganese (Mn) is associated with various neurobehavioral and movement dysfunctions. However, few studies have systemically examined the neurochemical effects of Mn exposure.

Objectives

We examined typical changes in cerebral metabolite ratios in welders chronically exposed to Mn, compared with control individuals, using proton magnetic resonance spectroscopy (MRS), investigated whether an abnormality in brain metabolism is associated with neurobehavioral changes, and assessed possible implications of chronic Mn exposure.

Methods

Thirty-five welders chronically exposed to Mn and 20 age-matched healthy subjects underwent single-voxel MRS at short echo time to assess the N-acetylaspartate (NAA), myoinositol (mI), total choline (tCho), and glutamine plus glutamate (Glx) levels, each of which was expressed as a ratio to total creatine (tCr). Neurobehavioral tests were also performed to define cognitive status.

Results

NAA/tCr, Glx/tCr, and tCho/tCr ratios in the frontal gray matter (anterior cingulate cortex; ACC) and parietal white matter did not differ significantly between welders and control subjects. These metabolite ratios did not correlate significantly with blood Mn concentration or neurobehavioral parameters. However, mI levels in the ACC, but not in the parietal white matter, were significantly reduced in welders compared with control individuals (P < 0.01). Furthermore, in the frontal lobe of the brain, the mI/tCr ratio was significantly correlated with verbal memory scores as well as blood Mn concentration (P < 0.05).

Conclusions

The cognitive decline observed in welders exposed to Mn was associated with a decreased mI/tCr ratio in the ACC. The depletion of mI in welders may reflect possible glial cell swelling and/or detoxification processes associated with long-term exposure to Mn.

Keywords
Manganese (Mn);
Magnetic resonance spectroscopy (MRS);
Welder;
Glial cell;
Neurotoxin;
Neuropsychological;
Imaging;
Neurobehavioral;
Neurodegeneration
Keimyung Author(s)(Kor)
정인성
Publisher
School of Medicine
Citation
Yongmin Chang et al. (2009). Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy. NeuroToxicology, 30(6), 950–957. doi: 10.1016/j.neuro.2009.07.008
Type
Article
ISSN
0161-813X
Source
https://www.sciencedirect.com/science/article/pii/S0161813X09001636?via%3Dihub
DOI
10.1016/j.neuro.2009.07.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33556
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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