Correlation of Primary Tumor FDG Uptake with Histopathologic Features of Advanced Gastric Cancer
- Author(s)
- Hae Won Kim; Kyoung Sook Won; Bong-Il Song; Yu Na Kang
- Keimyung Author(s)
- Kim, Hae Won; Won, Kyoung Sook; Song, Bong Il; Kang, Yu Na
- Department
- Dept. of Nuclear Medicine (핵의학)
Dept. of Pathology (병리학)
- Journal Title
- Nuclear Medicine and Molecular Imaging
- Issued Date
- 2015
- Volume
- 49
- Issue
- 2
- Keyword
- Gastric carcinoma; WHO classification; Lauren classification; Ming classification; PET/CT; FDG
- Abstract
- Purpose Histopathologic features could affect the FDG uptake
of primary gastric cancer and detection rate on FDG
PET/CT. The aim of this study was to evaluate the FDG uptake
of primary gastric cancer by correlating it with the histopathologic
features of the tumors.
Methods Fifty patients with locally advanced gastric adenocarcinoma
who were referred for preoperative FDG-PET/CT
scans were enrolled in this study. The detection rate of PET/
CTandmaximumstandardized uptake values (SUVmax) of the
primary tumor were compared using the WHO, Lauren,Ming
and Borrmann classifications and tumor size and location.
Results In 45 of the 50 patients (90 %), the primary gastric
tumors were detected by FDG PET/CT. On comparison using
the WHO classification, the detection rate and SUVmax of the
tubular type were significantly higher than those of the poorly
cohesive type. On comparison using the Lauren and Ming
classifications, the SUVmaxs of the intestinal type and
expanding type were significantly higher than those of the
diffuse and infiltrative type, respectively. On comparison
using the Borrmann classification and tumor size and location,
there was no significant difference in the detection rate and
SUVmax of primary gastric tumors.
Conclusion This study demonstrates that the poorly cohesive
type according to theWHO classification, diffuse type according
to the Lauren classification and infiltrative type according
to the Ming classification have low FDG uptake in patients
with locally advanced gastric carcinoma. Understanding the
relationship between primary tumor FDG uptake and histopathologic
features would be helpful in detecting the primary
tumor by FDG PET/CT in patients with gastric cancer.
Keywords Gastric carcinoma .WHO classification . Lauren
classification . Ming classification . PET/CT . FDG
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