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Significance of SUV on Follow-up F-18 FDG PET at the Anastomotic Site of Gastroduodenostomy after Distal Subtotal Gastrectomy in Patients with Gastric Cancer

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Author(s)
Byung Wook ChoiSeok Kil ZeonSung Hun KimIl JoHae Won KimKyoung Sook Won
Keimyung Author(s)
Zeon, Seok KilKim, Hae WonWon, Kyoung Sook
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
Nuclear Medicine and Molecular Imaging
Issued Date
2011
Volume
45
Issue
4
Keyword
F-18 fluorodeoxyglucosePETStomach cancerBillroth IGastroduodenostomyAnastomotic site
Abstract
Purpose The aim of this study was to characterize the
patterns of fluorodeoxyglucose (FDG) uptake on F-18 FDG
positron emission tomography/computed tomography
(FDG PET/CT) at the anastomotic site of gastroduodenostomy
after distal subtotal gastrectomy in patients with
gastric cancer.
Methods From May 2007 to May 2010, two or more
follow-up measurements using FDG PET/CT scans were
done for 19 patients (11 men, 8 women; mean age, 62.0±
10.3 years) who underwent distal subtotal gastrectomy with
gastroduodenostomy between February 2006 and March
2008 for detecting gastric cancer recurrence at our medical
center. The FDG PET/CT images were retrospectively
reviewed. Patients with local recurrence, regional nodal
metastasis or distant metastasis on follow-up studies were
excluded. CT and endoscopy were done within 1 month
before or after the FDG PET/CT scan. Eight patients had
two follow-ups of FDG PET/CT, and 11 patients had three
follow-ups. The mean interval between surgery and the first
follow-up FDG PET/CT was 12.9±0.8 months (n=19);
between the first and second it was 12.3±1.0 months (n=
19); between the second and third it was 11.6±0.7 months
(n=11). The F-18 FDG uptakes at the anastomotic site and
fundus in the remnant stomach were measured by maximum
standardized uptake value (SUVmax) using a region of
interest technique.
Results The SUVmax at the anastomotic site was significantly
higher than that of the fundus on all series of first,
second and third follow-up studies (3.3±1.1 vs. 2.1±0.7,
p<0.001: 3.1±0.9 vs. 2.2±0.7, p=0.001: 3.0±0.6 vs.
2.1±0.7, p=0.006, respectively). The SUVmax for the
anastomotic site and fundus, and SUVmax ratio for the
anastomotic site over the fundus were not significantly
different throughout the series.
Conclusion The SUVmax at the anastomotic site is
significantly higher than that of the fundus and does not
decrease significantly over time. Therefore, the local
recurrence of gastric cancer after surgery could not be
definitely differentiated from physiologic uptake or postoperative
inflammatory change.
Keywords F-18 fluorodeoxyglucose . PET. Stomach
cancer . Billroth I . Gastroduodenostomy. Anastomotic site
Keimyung Author(s)(Kor)
전석길
김해원
원경숙
Publisher
School of Medicine
Citation
Byung Wook Choi et al. (2011). Significance of SUV on Follow-up F-18 FDG PET at the Anastomotic Site of Gastroduodenostomy after Distal Subtotal Gastrectomy in Patients with Gastric Cancer. Nuclear Medicine and Molecular Imaging, 45(4), 285–290. doi: 10.1007/s13139-011-0105-9
Type
Article
ISSN
1869-3474
DOI
10.1007/s13139-011-0105-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33568
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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