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Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients

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Author(s)
JEI-JUN BAEJIN-WOO RHOTAE-JIN LEESUNG-SU YUNHONG-JIN KIMJOON-HYUK CHOIDAEWON JEONGBYEONG-CHURL JANGTAE-YOON LEE
Keimyung Author(s)
Jang, Byeong Churl
Department
Dept. of Molecular Medicine (분자의학)
Institute for Medical Science (의과학연구소)
Journal Title
Oncology Reports
Issued Date
2007
Volume
18
Issue
4
Keyword
hepatocellular carcinomaphosphatase and tensin homolog deleted from chromosome 1010q23loss of heterozygosityalterationmutation
Abstract
Loss of heterozygosity (LOH) in the 10q23 chromosomal region was analyzed in 18 tissue samples from Korean hepatocellular carcinoma (HCC) patients. LOH at the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) region (D10S215, AFMa086wg9 and D10S541) was found in 8 of the 18 (44.4%) HCCs. LOH (20%) and microsatellite instability (26.7%) were also frequently found at the D10S2177 locus, which is located on the telomere side of the PTEN region. LOH was found in other loci, such as AFM280we1 and D10S2281. The presence of LOH in regions other than the PTEN region on chromosome 10q23 suggested the presence of additional tumor suppressor gene(s). PTEN mutation was found in only a subset of HCCs: A single base insertion at the end of the 5'-end splice signal (AG-GUAAGUU) in intron 5 and a silent mutation in exon 6 (codon 188, CTG-Val to CTA). Our data collectively suggest that the genetic alterations of chromosome 10q23, including the PTEN gene, could be important in hepatocarcinogenesis in the Korean population.
Key words: hepatocellular carcinoma, phosphatase and tensin
homolog deleted from chromosome 10, 10q23, loss of heterozygosity,
alteration, mutation
Keimyung Author(s)(Kor)
장병철
Publisher
School of Medicine
Citation
JEI-JUN BAE et al. (2007). Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. Oncology Reports, 18(4), 1007–1013. doi: 10.3892/or.18.4.1007
Type
Article
ISSN
1021-335X
Source
https://www.spandidos-publications.com/or/18/4/1007
DOI
10.3892/or.18.4.1007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33600
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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