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Expression of EGFR and follicular dendritic markers in lymphoid follicles from patients with Castleman's disease

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Author(s)
JUHIE LEEJU YEON BANKYU YEOUN WONGYO-YONG KIMSUNG-JIG LIMSUN LEEYOUN WHA KIMYONG-KOO PARKSANG SOOK LEE
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Oncology Reports
Issued Date
2008
Volume
20
Issue
4
Keyword
Castleman's diseasefollicular dendritic cellsepidermal growth factor receptorhyaline vascular variantplasma cell variantimmunohistochemistrytissue microarray
Abstract
This study investigated the useful morphologic and
immunophenotypic findings for the diagnosis of Castleman's
disease (CD). We focused on the distribution and expression
of follicular dendritic cells (FDC) in lymphoid follicles from
patients with CD. Eleven CD cases of the hyaline vascular
(HV) variant and six cases of the plasma cell (PC) variant
were studied using tissue microarray and paraffin resistant
monoclonal antibodies CD21, CD35, and EGFR, a new novel
marker of FDC, as well as an antibody against human herpes
virus 8 (HHV8). Epstein-Barr virus (EBV) was detected by
means of in situ hybridization with a fluorescein isothiocyanate-
labeled EBV-encoded RNA (EBER) specific oligonucleotide.
The FDC network of the PC variant (n=4) was
similar to that seen in normal or reactive germinal centers. In
contrast, all HV variants and 2 cases of the PC variant were
either expanded, disrupted, or exhibited multiple tight
collections of FDC both in germinal centers and in mantle
zone lymphocytes. The expanded mantle zone lymphocytes
were CD20+, Bcl2+, PAX5+, and MUM1- with less number of
CD3+ T cells admixed. Other features of the HV variant
included follicular regression and vascular ingrowth of the
germinal centers, whereas features of the PC variant were
follicular hyperplasia and interfollicular plasmacytosis. In
addition, EBV infection was positive in three CD cases, and
one case had co-expression of HHV8 and EBV infection.
Taken together, we found immunophenotypic differences
of mantle zone lymphocytes and FDC network patterns of
lymphoid follicles in CD. Thus, we conclude that these
differences are relevant for the differential diagnosis of the
two histopathologic variants of CD.
Key words: Castleman's disease, follicular dendritic cells, epidermal
growth factor receptor, hyaline vascular variant, plasma cell variant,
immunohistochemistry, tissue microarray
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
JUHIE LEE et al. (2008). Expression of EGFR and follicular dendritic markers in lymphoid follicles from patients with Castleman’s disease. Oncology Reports, 20(4), 851–856. doi: 10.3892/or_00000082
Type
Article
ISSN
1021-335X
Source
https://www.spandidos-publications.com/or/20/4/851
DOI
10.3892/or_00000082
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33610
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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