계명대학교 의학도서관 Repository

Expression of EZH2 in renal cell carcinoma as a novel prognostic marker

Metadata Downloads
Author(s)
Hye Won LeeMisun Choe
Keimyung Author(s)
Lee, Hye WonChoe, Mi Sun
Department
Dept. of Pathology (병리학)
Journal Title
Pathology International
Issued Date
2012
Volume
62
Issue
11
Keyword
enhancer of zeste homolog 2immunohistochemistrykidneyprognosisrenal cell carcinoma
Abstract
Enhancer of zeste homolog 2 (EZH2) is a member of the Polycomb group proteins and a part of Polycomb repressive complex 2. EZH2 is important for transcriptional regulation through nucleosome modification and interaction with other transcription factors. Particularly, aberration of EZH2 has been implicated in oncogenesis and progression of various neoplasms. The objective of this study was to evaluate EZH2 expression in renal cell carcinoma (RCC), especially clear cell RCC (CRCC) and correlate the expression with prognostic factors. EZH2 expression was determined by immunohistochemical staining with additional Western blotting. High expression of EZH2 was significantly correlated with higher pT stage or more frequent distant metastases (P= 0.001 and 0.024, respectively). Survival analyses displayed that patients with high EZH2 expression had a significantly shorter disease-free survival than those with low expression (P= 0.019). High expression of EZH2 tended to reduce the overall survival, however, differences did not reach statistical significance (P= 0.066). From our results, we propose that EZH2 is a useful prognostic marker for aggressive behavior of CRCC and may be applicable as a therapeutic target molecule.
Keywords:

enhancer of zeste homolog 2;
immunohistochemistry;
kidney;
prognosis;
renal cell carcinoma
Keimyung Author(s)(Kor)
이혜원
최미선
Publisher
School of Medicine
Citation
Hye Won Lee and Misun Choe. (2012). Expression of EZH2 in renal cell carcinoma as a novel prognostic marker. Pathology International, 62(11), 735–741. doi: 10.1111/pin.12001
Type
Article
ISSN
1320-5463
DOI
10.1111/pin.12001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33643
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.