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Practical utility of insulin-like growth factor II mRNA-binding protein 3, glucose transporter 1, and epithelial membrane antigen for distinguishing malignant mesotheliomas from benign mesothelial proliferations

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Author(s)
Sunhee ChangMee-Hye OhSun-Young JiJoungho HanTae-Jung KimMinseob EomKun Young KwonSeung Yeon HaYoo Duk ChoiChang Hun LeeYonghee LeeSoon-Hee Jung
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Pathology International
Issued Date
2014
Volume
64
Issue
12
Keyword
epithelial membrane antigenglucose transporter type 1immunohistochemistryinsulin-like growth factor II mRNA-binding protein 3mesothelioma
Abstract
The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care and prognosis. But, this distinction can be extremely difficult, particularly in small biopsies. Recently, insulin-like growth factor II mRNA-binding protein 3 (IMP3) and glucose transporter 1 (GLUT-1) have been reported as specific and sensitive markers in the distinction of mesotheliomas from benign mesothelial proliferations. The purpose of this study is to evaluate the utility of IMP3, GLUT-1, and epithelial membrane antigen (EMA) immunohistochemistry for distinguishing mesotheliomas from benign mesothelial proliferations. Immunoexpression of IMP3, GLUT-1, and EMA was evaluated in 88 malignant mesotheliomas, 35 adenomatoid tumors, and 20 benign lung tissues with reactive mesothelial cells. The sensitivity for IMP3, GLUT-1, and EMA was 37%, 21%, and 41%, respectively. The specificity for IMP3, GLUT-1, and EMA was 100%. When IMP3, GLUT1, and EMA combined, the sensitivity was 66% for IMP3/EMA staining, 53% for GLUT-1/EMA staining, and 45% for IMP3/GLUT-1. Use of IMP3 and EMA together is more helpful to distinguish malignant mesotheliomas from benign mesothelial proliferations than the use of IMP3 or EMA alone.

© 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.


KEYWORDS:

epithelial membrane antigen; glucose transporter type 1; immunohistochemistry; insulin-like growth factor II mRNA-binding protein 3; mesothelioma
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Sunhee Chang et al. (2014). Practical utility of insulin-like growth factor II mRNA-binding protein 3, glucose transporter 1, and epithelial membrane antigen for distinguishing malignant mesotheliomas from benign mesothelial proliferations. Pathology International, 64(12), 607–612. doi: 10.1111/pin.12216
Type
Article
ISSN
1320-5463
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pin.12216
DOI
10.1111/pin.12216
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33645
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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