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Childhood ITP: 12 months follow-up data from the prospective registry I of the Intercontinental Childhood ITP Study Group (ICIS)

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Author(s)
P. ImbachT. KühneD. MüllerW. BerchtoldS. ZimmermanM. ElalfyG.R. Buchanan
Keimyung Author(s)
Kim, Heung Sik
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Pediatric Blood Cancer
Issued Date
2006
Volume
46
Issue
3
Keyword
acutechildchronicidiopathic thrombocytopenic purpurarecoveryregistry
Abstract
Background. Acute and chronic idiopathic
thrombocytopenic purpura (ITP) is traditionally
based on the duration of thrombocytopenia at
the cut-off point of 6 months after diagnosis.
Registry I evaluated the diagnosis, definition,
management, and follow-up of childhood ITP.
This report focuses on children with thrombocytopenia
persisting more than 6 months.
Procedure. Data were collected by questionnaires
to the physicians caring for children with
ITP, at diagnosis, 6, and 12 months later. Data
were compared regarding initial features and
follow-up with emphasis on children with persistent
thrombocytopenia, and those with ITP who
recovered their platelet counts between 7 and
12 months from diagnosis. Results. At 12 months
from diagnosis, 79 of 308 (25.6%) evaluable
children recovered from ITP and 229 had ongoing
ITP. Children with recovered ITP were younger
than children with ongoing ITP (P¼0.043) and
exhibited a lower frequency of bleeding symptoms
during the first 6 months after diagnosis
(P¼0.018). Frequency of hospitalization, bone
marrow aspiration, and drug treatment differed
regionally. Conclusions. The high rate of recovery
from ITP between 7 to 12 months demonstrates,
that the cut-off point of 6 months for the
definition of chronic ITP does not adequately
differentiate chronic from acute ITP. The majority
of children with ITP have variable time to
recovery with gradual improvement of platelet
counts and disappearance of bleeding signs.
ITP is a heterogeneous disorder with a diverse
natural history and diverse pattern of treatment
response. Pediatr Blood Cancer 2006;46:351–
356. 2005 Wiley-Liss, Inc.
Key words: acute; child; chronic; idiopathic thrombocytopenic purpura; recovery;
registry
Keimyung Author(s)(Kor)
김흥식
Publisher
School of Medicine
Citation
P. Imbach et al. (2006). Childhood ITP: 12 months follow-up data from the prospective registry I of the Intercontinental Childhood ITP Study Group (ICIS). Pediatric Blood Cancer, 46(3), 351–356. doi: 10.1002/pbc.20453
Type
Article
ISSN
1545-5009
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.20453
DOI
10.1002/pbc.20453
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33650
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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