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Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease

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Author(s)
Geum-Chae-Won YiKa-Hyun YoonJin-Bok Hwang
Keimyung Author(s)
Hwang, Jin Bok
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Pediatric Gastroenterology, Hepatology & Nutrition
Issued Date
2012
Volume
15
Issue
4
Keyword
Crohn diseaseInflammatory bowel diseasesAcute pancreatitisAzathioprine6-mercaptopurineMesalamineChild
Abstract
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test
in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever
and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography
revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms
and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse
drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine
showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low
dose challenge test and its interpretation for drug-induced pancreatitis. (Pediatr Gastroenterol Hepatol Nutr 2012;
15: 272∼275)
Key Words: Crohn disease, Inflammatory bowel diseases, Acute pancreatitis, Azathioprine, 6-mercaptopurine,
Mesalamine, Child
Keimyung Author(s)(Kor)
황진복
Publisher
School of Medicine
Citation
Geum-Chae-Won Yi et al. (2012). Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease. Pediatric Gastroenterology, Hepatology & Nutrition, 15(4), 272–275. doi: 10.5223/pghn.2012.15.4.272
Type
Article
ISSN
2234-8646
DOI
10.5223/pghn.2012.15.4.272
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33652
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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