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Chronic Peritoneal Inflammation by Cyanate in Rats

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Author(s)
Kyo-Cheol MunMi-Young YeoSang-Pyo KimHyun-Chul KimChun-Sik Kwak
Keimyung Author(s)
Mun, Kyo CheolKwak, Chun SikKim, Sang PyoKim, Hyun Chul
Department
Dept. of Biochemistry (생화학)
Dept. of Pathology (병리학)
Dept. of Internal Medicine (내과학)
Institute for Medical Science (의과학연구소)
Journal Title
Peritoneal Dialysis International
Issued Date
2000
Volume
20
Issue
6
Keyword
Carbamylationcyanateperitoneumchronic peritonitisurea
Abstract
is exposed to waste products, including urea. Urea forms
cyanate spontaneously at body temperature and pH, and
cyanate carbamylates amino acids, peptides, and proteins.
Cyanate may contribute to peritoneal injury with morphological
changes in the peritoneum. To test this hypothesis,
we injected cyanate into rats.
♦ Methods: Experiments were performed in two groups
of 7 rats each. In the cyanate group, each rat received
1 mL of 1.5 μmol/L potassium cyanate dissolved in
40 mmol/L sodium bicarbonate solution intraperitoneally
each experiment day. In the control group, each rat received
1 mL of 1.5 μmol/L potassium bicarbonate instead
of potassium cyanate. The rats in both groups were anesthetized
and killed at the 85th day after the first injection.
After formalin fixation, tissue samples from abdominal
walls and livers were sliced, embedded in a standard
manner, and stained with hematoxylin and eosin.
♦ Results: Parietal peritoneum from rats in the cyanate
group showed a mild increase in the number of fibroblasts,
with collagen deposits, infiltration by mononuclear cells,
vascular congestion, round-shaped transformation of mesothelial
cells, widening of submesothelial spaces, and
abundant denudation of mesothelial cells. The visceral
peritoneum from rats in the cyanate group showed collagen
deposits with fibroblastic proliferation.
♦ Conclusions: Cyanate can induce chronic inflammation
in the peritoneum, and exposure of the peritoneum
to cyanate may contribute to peritoneal injury in patients
being treated with peritoneal dialysis.
KEY WORDS: Carbamylation; cyanate; peritoneum;
chronic peritonitis; urea.
Keimyung Author(s)(Kor)
문교철
곽춘식
김상표
김현철
Publisher
School of Medicine
Citation
Kyo-Cheol Mun et al. (2000). Chronic Peritoneal Inflammation by Cyanate in Rats. Peritoneal Dialysis International, 20(6), 699–702.
Type
Article
ISSN
0896-8608
Source
http://www.pdiconnect.com.proxy.dsmc.or.kr/content/20/6/699.long
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33661
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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