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Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils

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Author(s)
Hyeon-Ju KimSeong-Ryong LeeKwang-Deog Moon
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Brain Research Institute (뇌연구소)
Journal Title
Phytotherapy Research
Issued Date
2003
Volume
17
Issue
8
Keyword
Gastrodia elataglobal brain ischemiahippocampusneuroprotection
Abstract
Gastrodia elata (GE), a medicinal herb, has been used traditionally for the treatment of convulsive diseases
such as epilepsy in oriental countries including South Korea and still occupies an important place in traditional
medicine in Asia. We designed this study to examine whether the ether fraction of methanol extracts (EFME)
of GE protects the hippocampal neuronal damage induced by transient global ischemia in a gerbil model.
Gerbils were treated with the EFME of GE (200 or 500 mg/kg per day, p.o.) for 14 days before brain ischemia.
The lower dose of EFME of GE failed to attenuate the hippocampal neuronal damage in the CA1 region.
However, the higher dose of EFME of GE attenuated the hippocampal neuronal damage in the CA1
region. The present results show that the EFME of GE has a protective effect against neuronal damage
following global ischemia in gerbils. Copyright © 2003 John Wiley & Sons, Ltd.
Keywords: Gastrodia elata; global brain ischemia; hippocampus; neuroprotection.
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine
Citation
Hyeon-Ju Kim et al. (2003). Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils. Phytotherapy Research, 17(8), 909–912. doi: 10.1002/ptr.1246
Type
Article
ISSN
0951-418X
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.1246
DOI
10.1002/ptr.1246
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33670
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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