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Use of vascularized periosteum or bone to improve healing of segmental allografts after tumor resection: an ovine rib model

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Author(s)
David W. ChangWilliam C. SatterfieldDaegu SonNicole NetoJohn E. MadewellA. Kevin RaymondCharles W. Patrick Jr.Michael J. MillerColleen M. CostelloeKristy L. Weber
Keimyung Author(s)
Son, Dae Gu
Department
Dept. of Plastic Surgery (성형외과학)
Journal Title
Plastic and Reconstructive Surgery
Issued Date
2009
Volume
123
Issue
1
Abstract
BACKGROUND:
Despite technical advances, nonunion or delayed union remains an important clinical problem when segmental allografts are used to repair diaphyseal defects after bone tumor resection. Using an ovine rib model, the authors studied whether the addition of a vascularized periosteum or bone flap improved healing compared with a segmental allograft alone.

METHODS:
A 4-cm segment of rib was resected from four consecutive ribs of 15 sheep. Three different reconstructions were compared within the same sheep: allograft alone, allograft and vascularized periosteum, and allograft and vascularized bone. One defect was not reconstructed and served as a control. Five sheep were humanely killed at each of the following time points: 9, 12, and 15 weeks. The host-allograft junctions were analyzed using plain radiographs, micro-computed tomography, and histologic examination.

RESULTS:
Micro-computed tomographic analysis showed significant improvement with each reconstruction technique over time. Plain radiographs and histologic analyses demonstrated earlier bridging of the host-allograft junction when either vascularized periosteum or vascularized bone was used compared with allograft alone.

CONCLUSION:
Use of vascularized periosteum or bone may facilitate healing of the host-allograft junction after intercalary allograft reconstruction.
Keimyung Author(s)(Kor)
손대구
Publisher
School of Medicine
Citation
David W. Chang et al. (2009). Use of vascularized periosteum or bone to improve healing of segmental allografts after tumor resection: an ovine rib model. Plastic and Reconstructive Surgery, 123(1), 71–78. doi: 10.1097/PRS.0b013e3181904baf
Type
Article
ISSN
0032-1052
Source
https://insights.ovid.com/pubmed?pmid=19116538
DOI
10.1097/PRS.0b013e3181904baf
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33679
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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