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Genetic Characteristics of Mitochondrial DNA Was Associated with Colorectal Carcinogenesis and Its Prognosis

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Author(s)
Jae-Ho LeeIlseon HwangYu-Na KangIn-Jang ChoiDae-Kwang Kim
Keimyung Author(s)
Lee, Jae HoChoi, In JangHwang, Il SeonKang, Yu NaKim, Dae Kwang
Department
Dept. of Anatomy (해부학)
Dept. of Pathology (병리학)
Dept. of Medical Genetics (의학유전학)
Journal Title
PLoS One
Issued Date
2015
Volume
10
Issue
3
Abstract
Clinical value of mitochondrial DNA has been described in colorectal cancer (CRC). To clarify its role in colorectal carcinogenesis, mitochondrial microsatellite instability (mtMSI) and other markers were investigated in CRCs and their precancerous lesions, as a multitier genetic study. DNA was isolated from paired normal and tumoral tissues in 78 tubular adenomas (TAs), 34 serrated polyps (SPs), and 100 CRCs. mtMSI, nucleus microsatellite instability (nMSI), KRAS mutation, and BRAF mutation were investigated in these tumors and their statistical analysis was performed. mtMSI was found in 30% of CRCs and 21.4% of precancerous lesions. Mitochondrial copy number was higher in SPs than TAs and it was associated with mtMSI in low grade TAs. KRAS and BRAF mutations were mutually exclusive in TAs and SPs. CRCs with mtMSI showed shorter overall survival times than the patients without mtMSI. In CRCs without nMSI or BRAF mutation, mtMSI was a more accurate marker for predicting prognosis. The genetic change of mitochondrial DNA is an early and independent event in colorectal precancerous lesions and mtMSI and mitochondrial contents are associated with the tubular adenoma-carcinoma sequence, resulting in poor prognosis. This result suggested that the genetic change in mitochondrial DNA appears to be a possible prognosis marker in CRC.
Keimyung Author(s)(Kor)
이재호
최인장
황일선
강유나
김대광
Publisher
School of Medicine
Citation
Jae-Ho Lee et al. (2015). Genetic Characteristics of Mitochondrial DNA Was Associated with Colorectal Carcinogenesis and Its Prognosis. PLoS One, 10(3), e0118612–e0118612. doi: 10.1371/journal.pone.0118612
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0118612
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33687
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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