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Lead-Induced Impairments in the Neural Processes Related to Working Memory Function

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Author(s)
Jeehye SeoByung-Kook LeeSeong-Uk JinJang Woo ParkYang-Tae KimHun-Kyu RyeomJongmin LeeKyung Jin SuhSuk Hwan KimSin-Jae ParkKyoung Sook JeongJung-O HamYangho KimYongmin Chang
Keimyung Author(s)
Kim, Yang Tae
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
PLoS One
Issued Date
2014
Volume
9
Issue
8
Abstract
Background

It is well known that lead exposure induces neurotoxic effects, which can result in a variety of neurocognitive dysfunction. Especially, occupational lead exposures in adults are associated with decreases in cognitive performance including working memory. Despite recent advances in human neuroimaging techniques, the neural correlates of lead-exposed cognitive impairment remain unclear. Therefore, this study was aimed to compare the neural activations in relation to working memory function between the lead-exposed subjects and healthy controls.

Methodology/Principal Findings

Thirty-one lead-exposed subjects and 34 healthy subjects performed an n-back memory task during MRI scan. We performed fMRI using the 1-back and 2-back memory tasks differing in cognitive demand. Functional MRI data were analyzed using within- and between-group analysis. We found that the lead-exposed subjects showed poorer working memory performance during high memory loading task than the healthy subjects. In addition, between-group analyses revealed that the lead-exposed subjects showed reduced activation in the dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, pre supplementary motor areas, and inferior parietal cortex.

Conclusions/Significance

Our findings suggest that functional abnormalities in the frontoparietal working memory network might contribute to impairments in maintenance and manipulation of working memory in the lead-exposed subjects.
Keimyung Author(s)(Kor)
김양태
Publisher
School of Medicine
Citation
Jeehye Seo et al. (2014). Lead-Induced Impairments in the Neural Processes Related to Working Memory Function. PLoS One, 9(8), e105308–e105308. doi: 10.1371/journal.pone.0105308
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0105308
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33690
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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