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Survival Nomogram for Curatively Resected Korean Gastric Cancer Patients: Multicenter Retrospective Analysis with External Validation

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Author(s)
Woo Jin HyungDong Woo ShinJun Ho LeeBang Wool EomKeun Won RyuByung-Ho NamYunjin ParkHyuk-Joon LeeMin Chan KimGyu Seok ChoChan Young KimSeung Wan Ryu
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
PLoS One
Issued Date
2015
Volume
10
Issue
2
Abstract
Background

A small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer patients using a multicenter database.

Methods

We reviewed the clinicopathological and survival data of 2012 patients who underwent curative resection for gastric cancer between 2001 and 2006 at eight centers. Among these centers, six institutions were randomly assigned to the development set, and the other two centers were assigned to the validation set. Multivariate analysis using the Cox proportional hazard regression model was performed, and discrimination and calibration were evaluated by external validation.

Results

Multivariate analyses revealed that age, tumor size, lymphovascular invasion, depth of invasion, and metastatic lymph nodes were significant prognostic factors for overall survival. In the external validation, the concordance index was 0.831 (95% confidence interval, 0.784–0.878), and Hosmer-Lemeshow chi-square statistic was 3.92 (P = 0.917).

Conclusions

We developed and validated a nomogram to predict 5-year overall survival after curative resection for gastric cancer based on a multicenter database. This nomogram can be broadly applied even in general hospitals and is useful for counseling patients, and scheduling follow-up.
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine
Citation
Woo Jin Hyung et al. (2015). Survival Nomogram for Curatively Resected Korean Gastric Cancer Patients: Multicenter Retrospective Analysis with External Validation. PLoS One, 10(2), e0119671–e0119671. doi: 10.1371/journal.pone.0119671
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0119671
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33693
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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