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Decreased cortical complexity in methamphetamine abusers

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Author(s)
Kyongsik YunHee-Kwon ParkDo-Hoon KwonYang-Tae KimSung-Nam ChoHyun-Jin ChoBradley S. PetersonJaeseung Jeong
Keimyung Author(s)
Kim, Yang Tae
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Psychiatry Research: Neuroimaging
Issued Date
2012
Volume
201
Issue
3
Keyword
MethamphetamineEEGCortical dynamicsApproximate Entropy
Abstract
This study aimed to investigate if methamphetamine (MA) abusers exhibit alterations in complexity of the electroencephalogram (EEG) and to determine if these possible alterations are associated with their abuse patterns. EEGs were recorded from 48 former MA-dependent males and 20 age- and sex-matched healthy subjects. Approximate Entropy (ApEn), an information-theoretical measure of irregularity, of the EEGs was estimated to quantify the degree of cortical complexity. The ApEn values in MA abusers were significantly lower than those of healthy subjects in most of the cortical regions, indicating decreased cortical complexity of MA abusers, which may be associated with impairment in specialization and integration of cortical activities owing to MA abuse. Moreover, ApEn values exhibited significant correlations with the clinical factors including abuse patterns, symptoms of psychoses, and their concurrent drinking and smoking habits. These findings provide insights into abnormal information processing in MA abusers and suggest that ApEn of EEG recordings may be used as a potential supplementary tool for quantitative diagnosis of MA abuse. This is the first investigation to assess the “severity-dependent dynamical complexity” of EEG patterns in former MA abusers and their associations with the subjects' abuse patterns and other clinical measures.

Keywords
Methamphetamine;
EEG;
Cortical dynamics;
Approximate Entropy
Keimyung Author(s)(Kor)
김양태
Publisher
School of Medicine
Citation
Kyongsik Yun et al. (2012). Decreased cortical complexity in methamphetamine abusers. Psychiatry Research: Neuroimaging, 201(3), 226–232. doi: 10.1016/j.pscychresns.2011.07.009
Type
Article
ISSN
0925-4927
Source
http://lps3.linkinghub.elsevier.com.proxy.dsmc.or.kr/retrieve/pii/S0925-4927(11)00249-6
DOI
10.1016/j.pscychresns.2011.07.009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33713
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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