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Postoperative radiotherapy for endometrial cancer

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Affiliated Author(s)
김진희김옥배권상훈
Alternative Author(s)
Kim, Jin HeeKim, Ok BaeKwon, Sang Hoon
Journal Title
Radiation oncology journal
ISSN
2234-1900
Issued Date
2012
Keyword
Endometrial neoplasmPostoperative proceduresAdjuvant radiotherapyPrognosisMenopause
Abstract
Purpose: To investigate the prognostic factors and effectiveness of postoperative radiotherapy alone for endometrial carcinoma.
Materials and Methods: Sixty four patients with stage I–III endometrial cancer (EC) treated with postoperative radiotherapy alone between January 1989 and December 2008 at the Keimyung University Dongsan Medical Center were chosen for the present study. Typically, total hysterectomy, salpingo-oophorectomy and lymphadenectomy were performed on the patient’s pelvis. Total dose from 50.4 Gy to 63 Gy was irradiated at pelvis or extended field. Thirteen patients were treated with Co-60 or Ir-192 intracavitary radiotherapy. Follow-up periods were from 7 to 270 months, with a median of 56 months.
Results: Five year overall survival (OS) rate was 58.7%, respectively. Five year disease-free survival (DFS) rate was 59.2%, respectively. In univariate analysis for OS and DFS, stage, menopausal age, type of operation, serosal invasion, and lymph node involvement were found to be statistically significant. Histologic type was marginally significant. In multivariate analysis for OS and DFS, stage, types of operation, histologic type were also found to be statistically significant. Treatment failure occurred in 14 patients. The main pattern of failure was found to be distant metastasis. Time to distant metastasis was from 3 to 86 months (median, 12 months). There were no grade 3 or 4 complications.
Conclusion: Stage, types of operation, and histologic type could be the predictive prognostic factors in patients. We contemplated postoperative radiation as effective and safe treatment method for EC. Additional treatment would be needed to reduce distant metastasis.
Keywords: Endometrial neoplasm, Postoperative procedures, Adjuvant radiotherapy, Prognosis, Menopause
Department
Dept. of Radiation Oncology (방사선종양학)
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine
Citation
Eun Cheol Choi et al. (2012). Postoperative radiotherapy for endometrial cancer. Radiation oncology journal, 30(3), 108–116. doi: 10.3857/roj.2012.30.3.108
Type
Article
ISSN
2234-1900
DOI
10.3857/roj.2012.30.3.108
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33717
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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