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Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol

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Author(s)
Youngkeun AhnHa Mi KimKi Hong LeeMyung Ho JeongJong Hyun KimShung Chull ChaeYoung Jo KimSeung Ho HurIn Whan SeongTaek Jong HongDong Hoon ChoiMyeong Chan ChoChong Jin KimKi Bae SeungWook Sung ChungYang Soo JangSeung Woon RhaJang Ho BaeJeong Gwan ChoSeung Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of the American College of Cardiology
Issued Date
2011
Volume
58
Issue
16
Keyword
low-density lipoprotein cholesterolmyocardial infarctionstatin
Abstract
Objectives We investigated whether statin therapy could be beneficial in patients with acute myocardial infarction (AMI)
who have baseline low-density lipoprotein cholesterol (LDL-C) levels below 70 mg/dl.
Background Intensive lipid-lowering therapy with a target LDL-C value 70 mg/dl is recommended in patients with very
high cardiovascular risk. However, whether to use statin therapy in patients with baseline LDL-C levels below
70 mg/dl is controversial.
Methods We analyzed 1,054 patients with AMI who had baseline LDL-C levels below 70 mg/dl and survived at discharge
from the Korean Acute MI Registry between November 2005 and December 2007. They were divided into
2 groups according to the prescribing of statins at discharge (statin group n 607; nonstatin group n 447).
The primary endpoint was the composite of 1-year major adverse cardiac events, including death, recurrent MI,
target vessel revascularization, and coronary artery bypass grafting.
Results Statin therapy significantly reduced the risk of the composite primary endpoint (adjusted hazard ratio [HR]: 0.56;
95% confidence interval [CI]: 0.34 to 0.89; p 0.015). Statin therapy reduced the risk of cardiac death (HR:
0.47; 95% CI: 0.23 to 0.93; p 0.031) and coronary revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p
0.013). However, there were no differences in the risk of the composite of all-cause death, recurrent MI, and
repeated percutaneous coronary intervention rate.
Conclusions Statin therapy in patients with AMI with LDL-C levels below 70 mg/dl was associated with improved clinical
outcome.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Youngkeun Ahn et al. (2011). Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol. Journal of the American College of Cardiology, 58(16), 1664–1671. doi: 10.1016/j.jacc.2011.05.057
Type
Article
ISSN
0735-1097
DOI
10.1016/j.jacc.2011.05.057
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33719
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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