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Efficacy of Intra-Articular Injection of Thrombin-Based Hemostatic Agent in the Control of Bleeding after Primary Total Knee Arthroplasty

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Author(s)
Ki-Cheor BaeChul-Hyun ChoKyung-Jae LeeEun-Seok SonSi-Wook LeeSuk-Joong LeeKyung Hwan Lim
Keimyung Author(s)
Bae, Ki CheorCho, Chul HyunLee, Kyung JaeSon, Eun SeokLee, Si Wook
Department
Dept. of Orthopedic Surgery (정형외과학)
Journal Title
Knee Surgery and Related Research
Issued Date
2014
Volume
26
Issue
4
Keyword
Knee, OsteoarthritisArthroplastyBleedingHemostatic agent
Abstract
Purpose: To evaluate the hemostatic effect of intraarticular injection of a thrombin-based hemostatic agent in total knee arthroplasty (TKA).
Materials and Methods: We performed a prospective randomized controlled trial on the use of a thrombin-based hemostatic agent in patients
undergoing unilateral TKA. A total of 100 TKA patients were enrolled, with 50 patients randomized into the study group and the other 50 patients
into the controlled group. Drain output, hemoglobin level, total red blood cell loss for 24 hours after surgery, transfusion rates, and complications
were assessed.
Results: Postoperative drain output was 525 mL in the study group and 667 mL in the control group (p=0.01). Nine patients in the study group
and eighteen in the control group received blood transfusion (p=0.043). But, there was no significant difference between two groups in terms of
hemoglobin level change and total red blood cell loss (p>0.05).
Conclusions: The thrombin-based hemostatic agent demonstrated efficacy in reducing drain output and blood transfusion rates. Thus, we believe
the use of a thrombin-based hemostatic agent should be considered as an option in orthopedic surgery that involves massive bleeding.
Keimyung Author(s)(Kor)
배기철
조철현
이경재
손은석
이시욱
Publisher
School of Medicine
Citation
Ki-Cheor Bae et al. (2014). Efficacy of Intra-Articular Injection of Thrombin-Based Hemostatic Agent in the Control of Bleeding after Primary Total Knee Arthroplasty. Knee Surgery and Related Research, 26(4), 236–240. doi: 10.5792/ksrr.2014.26.4.236
Type
Article
ISSN
2234-0726
DOI
10.5792/ksrr.2014.26.4.236
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33733
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
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