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Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the Korean Acute Myocardial Infarction Registry

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Author(s)
Futoshi YamanakaMyung Ho JeongShigeru SaitoYoungkeun AhnShung Chull ChaeSeung Ho HurTaek Jong HongYoung Jo KimIn Whan SeongJei Keon ChaeJay Young RhewIn Ho ChaeMyeong Chan ChoJang Ho BaeSeung Woon RhaChong Jin KimDonghoon ChoiYang Soo JangJunghan YoonWook Sung ChungJeong Gwan ChoKi Bae SeungSeung Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Cardiology
Issued Date
2013
Volume
62
Issue
4
Keyword
ElderlyMyocardial infarctionTreatmentPrognosis
Abstract
Background and purpose.
Octogenarians (age ≥ 80 years) with coronary artery disease constitute a high-risk group. However, octogenarian patients with acute myocardial infarction (AMI) in the drug-eluting stents (DES) era have not been widely reported. We aimed to identify clinical outcomes in octogenarian compared with non-octogenarian AMI patients.

Methods and subjects.
We retrospectively analyzed 9877 patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and who were enrolled in the Korean Acute Myocardial Infarction Registry (KAMIR). They were divided into 2 groups, octogenarians (n = 1494) and non-octogenarians (n = 8383), in order to compare the incidence of 1-year all-cause death and 1-year major adverse cardiac events (MACE), where MACE included all-cause death, recurrent myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), and coronary artery bypass grafting (CABG).

Results.
The clinical status was significantly inferior in octogenarians compared to non-octogenarians: Killip class ≥ II (34.8% vs. 22.5%, p < 0.001), multivessel disease (65.8% vs. 53.7%, p < 0.001). Rates of 1-year all-cause death were significantly higher in octogenarians than in non-octogenarians (22.3% vs. 6.5%, p < 0.001). However, the rates of 1-year recurrent myocardial infarction (1.3% vs. 0.9%, p = 0.68), TLR (2.4% vs. 3.1%, p = 0.69), TVR (3.6% vs. 4.3%, p = 0.96), and CABG (0.9% vs. 0.9%, p = 0.76) did not differ significantly between the 2 groups.

Conclusions.
Octogenarian AMI patients have higher rates of mortality and MACE even in the DES era. According to KAMIR subgroup analysis, the TLR/TVR rates in octogenarians were comparable to those in non-octogenarian AMI patients.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Futoshi Yamanaka et al. (2013). Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the Korean Acute Myocardial Infarction Registry. Journal of Cardiology, 62(4), 210–216. doi: 10.1016/j.jjcc.2013.04.003
Type
Article
ISSN
0914-5087
Source
http://lps3.linkinghub.elsevier.com.proxy.dsmc.or.kr/retrieve/pii/S0914-5087(13)00137-8
DOI
10.1016/j.jjcc.2013.04.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33747
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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