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Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

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Author(s)
KUN HO YOONSEUNG HYUN KOJAE HYOUNG CHOJUNG MIN LEEYU BAE AHNKI HO SONGSOON JIB YOOMOO IL KANGBONG YUN CHAKWANG WOO LEEHO YOUNG SONSUNG KOO KANGHEE SEUNG KIMIN KYU LEESUSAN BONNER-WEIR
Keimyung Author(s)
Lee, In Kyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Endocrinology & Metabolism
Issued Date
2003
Volume
88
Issue
5
Keyword
A/B ratioRatio of the area of α-cells and β-cellsBMIbody mass indexDMdiabetes mellitus
Abstract
In the presence of obesity, β-cell mass needs to be increased to compensate for the accompanying demands and maintain euglycemia. However, in Korea, the majority of type 2 diabetic patients are nonobese. We determined the absolute masses, relative volumes, and ratio of α- and β-cell in the pancreas and islets in normal and diabetic Korean subjects to correlate these findings with the clinical characteristics. Whole pancreases procured from organ donors were divided into 24 parts (control 1, n = 9). Tissue was also obtained by surgical resection after 35 partial pancreatectomies: in 25 diabetic patients, 10 age- and body mass index (BMI)-matched patients of benign or malignant pancreatic tumor without diabetes mellitus (DM) (control 2). Morphometric quantifications were performed. In control 1, the relative volume of β-cells was 2.1 ± 0.9%, and the total β-cell mass was 1.3 ± 0.3 g. The relative volume of β-cells was found to be variable (control 1, 2.1 ± 0.9%; control 2, 1.9 ± 0.7%; DM, 1.4 ± 1.0%; P < 0.05 DM vs. control 1 and 2) and showed good correlation with BMI (control 1, r2 = 0.64; DM, r2 = 0.55; all subjects, r2 = 0.38; P < 0.05). Notably, in type 2 diabetic patients, the ratio of α-cell area to β-cell area in the islet was higher than in control 1 and 2 (0.81 ± 0.4 vs. 0.29 ± 0.2, 0.20 ± 0.1, P < 0.05). Additionally, significant α-cell expansion and a decreased β-cell fraction were predominantly observed in larger islets (islet area, >6415 μm2; P < 0.05) in control 1 and diabetic patients. The relative volume of β-cell was found to be correlated with BMI in diabetic patients and normal organ donors. Moreover, decreased β-cell but increased α-cell proportion in the islets suggests for a selective β-cell loss in the pathogenesis of Korean type 2 diabetes.
Keimyung Author(s)(Kor)
이인규
Publisher
School of Medicine
Citation
KUN HO YOON et al. (2003). Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea. Journal of Clinical Endocrinology & Metabolism, 88(5), 2300–2308. doi: 10.1210/jc.2002-020735
Type
Article
ISSN
0021-972X
DOI
10.1210/jc.2002-020735
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33754
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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