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Prevalence of Hepatitis-B Viral Markers in Patients With Inflammatory Bowel Disease in a Hepatitis-B-Endemic Area Inadequate Protective Antibody Levels in Young Patients

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Author(s)
Daegugyeongbuk Gastrointestinal Study Group (DGSG)Wan Jung KimEun Soo KimKwang Bum ChoKyung Sik ParkByung Ik JangKyeong Ok KimSeong Woo JeonEun Young KimChang Heon Yang
Keimyung Author(s)
Kim, Eun SooCho, Kwang BumPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Gastroenterology
Issued Date
2014
Volume
48
Issue
6
Keyword
Crohn’s diseaseulcerative colitishepatitis-B virusvaccination
Abstract
Background: There are few data regarding the prevalence of hepatitis-
B virus (HBV) markers in inflammatory bowel disease (IBD)
patients in Korea, which is a hepatitis-B-endemic area. The aim of
this study was to assess the prevalence of HBV markers in IBD
patients in comparison with controls.
Methods: We enrolled 513 IBD patients [241 Crohn’s disease (CD)
and 272 ulcerative colitis (UC)] whose hepatitis-B surface antigen
and anti-HBs levels were evaluated. Anti-HBc was assayed in 357
patients. These markers were compared with those of 1020 sexmatched
and age-matched controls.
Results: Prevalence of hepatitis-B surface antigen in IBD patients
was 3.7% and there was no significant difference between groups
(CD 4.1%, UC 3.3%, control 4.4%, P=0.713). The frequency of
effective vaccination against HBV (positive anti-HBs, without anti-
HBc) was lower in IBD patients less than 30 years old compared
with the same-aged controls (CD 43.3%, UC 48.5%, control
61.9%, P=0.002), whereas there was no difference between groups
in subjects more than 30 years old. One third of IBD patients were
at risk of susceptibility to HBV infection (nonimmune), particularly
those less than 30 years old, compared with controls of the same
age (CD 43.3%, UC 36.4%, control 21%, P<0.001). In IBD
patients, multivariate analysis identified that age less than 30 years
was an independent risk factor for nonimmune status.
Conclusions: IBD was not a risk factor for HBV infection even in
endemic areas. However, many young IBD patients were
susceptible to HBV infection. It is crucial to screen for HBV
immunity and to implement a meticulous vaccination strategy for
young Korean IBD patients.
Keimyung Author(s)(Kor)
김은수
조광범
박경식
Publisher
School of Medicine
Citation
Daegugyeongbuk Gastrointestinal Study Group (DGSG) et al. (2014). Prevalence of Hepatitis-B Viral Markers in Patients With Inflammatory Bowel Disease in a Hepatitis-B-Endemic Area Inadequate Protective Antibody Levels in Young Patients. Journal of Clinical Gastroenterology, 48(6), 553–558. doi: 10.1097/01.mcg.0000436435.75392.23
Type
Article
ISSN
0192-0790
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=24162170
DOI
10.1097/01.mcg.0000436435.75392.23
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33755
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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