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Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina

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Author(s)
Cheol Whan LeeIlseon HwangChan-Sik ParkHyangsin LeeDuk-Woo ParkSoo-Jin KangSeung-Whan LeeYoung-Hak KimSeong-Wook ParkSeung-Jung Park
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Clinical Pathology
Issued Date
2013
Volume
66
Issue
9
Abstract
Background: Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary atherosclerotic plaques or its relationship to plaque instability.


Objective: STC1 expression was examined in the culprit coronary plaques of 70 patients with acute myocardial infarction (AMI; n=49) or stable angina (n=21) who underwent directional coronary atherectomy.


Methods: The specimens were stained with H&E, STC1-specific antibodies, and endothelial cells, macrophages and smooth muscle cell markers.


Results: The baseline characteristics of the two groups of patients were largely similar. CD31-immunopositive and CD68-immunopositive areas, indicative of the presence of endothelial cells and macrophages, respectively, were proportionately larger while areas immunopositive for α-actin, as a smooth muscle cell marker, were proportionately smaller in the AMI group than in the stable angina group. The proportion of STC1-immunopositive areas was significantly greater in the AMI group than in the stable angina group (20.0% (8.2–29.0%) vs 8.8% (3.9–19.4%), p=0.022). Areas positive for STC1 were independently correlated with those immunopositive for CD31 (r=0.42, p<0.001) and CD68 (r=0.40, p<0.001). STC1 immunoreactivity co-localised with CD31-immunopositive and CD68-immunopositive cells.


Conclusions: STC1 is differentially expressed in the culprit coronary plaques of patients with AMI versus those with stable angina. STC1 may play a role in plaque instability.
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine
Citation
Cheol Whan Lee et al. (2013). Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina. Journal of Clinical Pathology, 66(9), 787–791. doi: 10.1136/jclinpath-2013-201563
Type
Article
ISSN
0021-9746
Source
http://jcp.bmj.com/content/66/9/787.long
DOI
10.1136/jclinpath-2013-201563
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33762
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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