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Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma

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Author(s)
Soo Hee KimJi-young ChoeYoonkyong JeonJooryung HuhHye Ra JungYoo-Duk ChoiHyun-Jung KimHee Jeong ChaWeon Seo ParkJi Eun Kim
Keimyung Author(s)
Jung, Hye Ra
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Clinical Pathology
Issued Date
2013
Volume
66
Issue
7
Abstract
Aims: Although the tumour cells of Hodgkin lymphoma (HL) are derived from mature B-cells, the lineage infidelity of Hodgkin/Reed–Sternberg cells (HRSs) often causes diagnostic problems. Recently introduced HRS markers are also positive for follicular dendritic cells (FDCs). We investigated the expression of several FDC markers in HL and anaplastic large cell lymphoma (ALCL) and evaluated their diagnostic efficacy.


Methods :Eighty-five cases of HL and 52 cases of ALCL were included in this study. Immunohistochemistry was performed for glioma-associated homologue (GLI) 3, class III β-tubulin (TUBB3), fascin, clusterin, γ-synuclein, podoplanin, syntenin, CD21, CD35 and EGFR.


Results: HRSs were diffusely positive for GLI3, fascin and TUBB3; the mean positivity rates per case were 94% for GLI3, 82% for fascin, 69% for TUBB3, 17% for clusterin, 17% for γ-synuclein and 14% for syntenin. Podoplanin, CD21, CD35 and EGFR were almost negative. However, the frequency of marker expression was not associated with the histologic subtype or the presence of Epstein–Barr virus (EBV). ALCL showed a similar pattern to HL, but the overall frequency of positivity was lower than that observed in HL. The mean positivity rates were 56% for GLI3, 62% for fascin, 58% for TUBB3 and 21% for clusterin. The other markers were nearly negative. Anaplastic large cell lymphoma kinase positivity did not affect the expression rates.


Conclusions: This study confirmed the frequent expression of FDC markers in HL and ALCL. Especially, GLI3, fascin and TUBB3 are the most sensitive markers. Further studies are required to evaluate the association between FDCs, HRSs and ALCL cells
Keimyung Author(s)(Kor)
정혜라
Publisher
School of Medicine
Citation
Soo Hee Kim et al. (2013). Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma. Journal of Clinical Pathology, 66(7), 589–596. doi: 10.1136/jclinpath-2012-201425
Type
Article
ISSN
0021-9746
Source
http://jcp.bmj.com/content/66/7/589.long
DOI
10.1136/jclinpath-2012-201425
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33763
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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