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Comparisons of Everolimus and Paclitaxel-Eluting Stents in Patients with Acute Myocardial Infarction

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Author(s)
KANG-YIN CHENSEUNG-WOON RHAYONG-JIAN LIGUANG-PING LIDONG JOO OHMYUNG HO JEONGYOUNG JO KIMSEUNG HO HURJANG HO BAETAE HOON AHNKOREA ACUTE MYOCARDIAL INFARCTION REGISTRY INVESTIGATORS
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Interventional Cardiology
Issued Date
2015
Volume
28
Issue
2
Abstract
Background: It has been established that the newer-generation drug-eluting stent (DES) everolimus-eluting stent
(EES) is superior to the first-generation DES paclitaxel-eluting stent (PES). However, the advantages of EES over
PES in the setting of acute myocardial infarction (AMI) need to be fully elucidated.
Methods: The present analysis enrolled 2,911 AMI patients receiving PES (n¼1,210) or EES (n¼1,701) in a largescale,
prospective, multicenter Korea Acute Myocardial Infarction Registry (KAMIR). Propensity score matching
was used to adjust for baseline biases in clinical and angiographic characteristics, yielding a total of 2,398 patients
(1,199 receiving PES and 1,199 receiving EES). Various clinical outcomes at 1 year were compared between the two
propensity score matched groups. Target lesion failure (TLF) was defined as the composite of cardiac death,
recurrent nonfatal myocardial infarction (Re-MI), or target lesion revascularization (TLR).
Results: Baseline clinical and angiographic characteristics were comparable between the two groups after
propensity score matching. Clinical outcomes of the propensity score matched patients showed that the rates of inhospital
and 1-year cardiac and all-cause death were similar between the two groups. But patients in the EES group
had significantly lower incidences of Re-MI (1.4% vs 2.8%, P¼0.002), TLR (1.2% vs 3.1%, P¼0.001), TLF (6.4%
vs 10.2%, P¼0.001), and probable or definite stent thrombosis (0.3% vs 1.8%, P<0.001) than did those in the PES
group.
Conclusions: The present propensity matched analysis suggests that the use of EES in the setting of AMI appears to
be superior to PES in reducing TLF, and stent thrombosis.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
KANG-YIN CHEN et al. (2015). Comparisons of Everolimus and Paclitaxel-Eluting Stents in Patients with Acute Myocardial Infarction. Journal of Interventional Cardiology, 28(2), 147–156. doi: 10.1111/joic.12187
Type
Article
ISSN
0896-4327
Source
http://dx.doi.org.proxy.dsmc.or.kr/10.1111/joic.12187
DOI
10.1111/joic.12187
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33790
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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