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Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Treatment, Survival Analysis in Korean Patients Older than 70 Years

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Author(s)
Yun Jung KimByoung Kuk JangEun Soo KimWoo Jin ChungKyung Sik ParkKwang Bum ChoJae Seok Hwang
Keimyung Author(s)
Jang, Byoung KukKim, Eun SooChung, Woo JinPark, Kyung SikCho, Kwang BumHwang, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2012
Volume
27
Issue
10
Keyword
Hepatocellular CarcinomaElderlySurvivalPrognosis
Abstract
The prevalence of hepatocellular carcinoma (HCC) has increased in recent years. However,
HCC remains poorly characterized in elderly patients, and comprehensive data are limited.
This study aimed to investigate the clinical characteristics, prognostic features and survival
outcome of elderly HCC patients. We retrospectively analyzed 992 HCC patients treated at
Dongsan Hospital from January 2003 to December 2007. The patients were divided into
two age groups: < 70 yr (n = 813) and ≥ 70 yr (n = 179). Elderly HCC patients, compared
to younger patients, had significantly higher incidence of females (31.3% vs 18.9%,
P = 0.001), hepatitis C-related disease (HCV antibody positivity 26.3% vs 9.2%, P = 0.001)
and comorbid condition (53.6% vs 32.1%), but lower rates of hepatitis B-related disease
(HBs antigen positivity 31.3% vs 69.4%, P = 0.001). There were no significant differences
in underlying liver function, stage and survival outcomes. Factors significantly influencing
the prognosis of HCC were Child-Pugh grade, number of HCC, level of alpha-fetoprotein,
presence of metastasis. The survival outcome of older patients with HCC was not different
from that of younger patients. There were no differences between groups in independent
factors influencing the prognosis of HCC. Therefore, determining the optimal management
strategy for elderly HCC patients is important to improve survival and long-term outcomes.
Keimyung Author(s)(Kor)
장병국
김은수
정우진
박경식
조광범
황재석
Publisher
School of Medicine
Citation
Yun Jung Kim et al. (2012). Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Treatment, Survival Analysis in Korean Patients Older than 70 Years. Journal of Korean Medical Science, 27(10), 1147–1154. doi: 10.3346/jkms.2012.27.10.1147
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2012.27.10.1147
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33803
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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