Infliximab Partially Alleviates the Bite Force Reduction in a Mouse Model of Temporomandibular Joint Pain
- Author(s)
- Sang-Hyon Kim; Chang-Nam Son; Hyo-Jung Lee; Ho-Chan Cho; Sung-Won Jung; Ji An Hur; .Won-Ki Baek; Hye Ra Jung; Ji Hee Hong
- Keimyung Author(s)
- Jung, Sung Won; Kim, Sang Hyon; Son, Chang Nam; Cho, Ho Chan; Jung, Hye Ra; Baek, Won Ki; Hong, Ji Hee
- Department
- Dept. of Psychiatry (정신건강의학)
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Microbiology (미생물학)
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
- Journal Title
- Journal of Korean Medical Science
- Issued Date
- 2015
- Volume
- 30
- Issue
- 5
- Keyword
- Bite Force; Infliximab; Temporomandibular Joint Pain
- Abstract
- TTemporomandibular joint (TMJ) disorder is clinically important because of its prevalence,
chronicity, and therapy-refractoriness of the pain. In this study, we investigated the effect
of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for
evaluating the changes in bite force (BF). The mice were randomly divided into three
groups (7 mice per group): the control group, the complete Freund’s adjuvant (CFA) group,
and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the
baseline BF, CFA or incomplete Freund’s adjuvant was injected into both TMJs and then the
changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For
measuring the BF, we used a custom-built BF transducer. Control, CFA, and infliximab
groups showed similar baseline BF at day 0. From day 1, a significant reduction in BF was
observed in the CFA group, and this reduction in BF was statistically significant compared
to that in the control group (P < 0.05). This reduction in BF was maintained until day 7,
and BF started to recover gradually from day 9. In the infliximab group also, the reduction
in BF was observed on day 1, and this reduction was maintained until day 7. However, the
degree of reduction in BF was less remarkable compared to that in the CFA group. The
reduction in BF caused by injection of CFA into the TMJ could be partially alleviated by the
injection of anti-tumor necrosis factor alpha, infliximab.
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