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Infliximab Partially Alleviates the Bite Force Reduction in a Mouse Model of Temporomandibular Joint Pain

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Author(s)
Sang-Hyon KimChang-Nam SonHyo-Jung LeeHo-Chan ChoSung-Won JungJi An Hur.Won-Ki BaekHye Ra JungJi Hee Hong
Keimyung Author(s)
Jung, Sung WonKim, Sang HyonSon, Chang NamCho, Ho ChanJung, Hye RaBaek, Won KiHong, Ji Hee
Department
Dept. of Psychiatry (정신건강의학)
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Microbiology (미생물학)
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Korean Medical Science
Issued Date
2015
Volume
30
Issue
5
Keyword
Bite ForceInfliximabTemporomandibular Joint Pain
Abstract
TTemporomandibular joint (TMJ) disorder is clinically important because of its prevalence,
chronicity, and therapy-refractoriness of the pain. In this study, we investigated the effect
of infliximab in a mouse model of TMJ pain using a specially-engineered transducer for
evaluating the changes in bite force (BF). The mice were randomly divided into three
groups (7 mice per group): the control group, the complete Freund’s adjuvant (CFA) group,
and the infliximab group. BF was measured at day 0 (baseline BF). After measuring the
baseline BF, CFA or incomplete Freund’s adjuvant was injected into both TMJs and then the
changes in BF were measured at days 1, 3, 5, 7, 9, and 13 after the TMJ injection. For
measuring the BF, we used a custom-built BF transducer. Control, CFA, and infliximab
groups showed similar baseline BF at day 0. From day 1, a significant reduction in BF was
observed in the CFA group, and this reduction in BF was statistically significant compared
to that in the control group (P < 0.05). This reduction in BF was maintained until day 7,
and BF started to recover gradually from day 9. In the infliximab group also, the reduction
in BF was observed on day 1, and this reduction was maintained until day 7. However, the
degree of reduction in BF was less remarkable compared to that in the CFA group. The
reduction in BF caused by injection of CFA into the TMJ could be partially alleviated by the
injection of anti-tumor necrosis factor alpha, infliximab.
Keimyung Author(s)(Kor)
정성원
김상현
손창남
조호찬
정혜라
백원기
홍지희
Publisher
School of Medicine
Citation
Sang-Hyon Kim et al. (2015). Infliximab Partially Alleviates the Bite Force Reduction in a Mouse Model of Temporomandibular Joint Pain. Journal of Korean Medical Science, 30(5), 552–558. doi: 10.3346/jkms.2015.30.5.552
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2015.30.5.552
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33816
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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