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The Protective Effect of Allopurinol on Cholestatic Liver Injury Induced by Bile Duct Ligation

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Author(s)
Kyo-Cheol MunChun-Sik KwakKun-Young Kwon
Keimyung Author(s)
Kwon, Kun YoungMun, Kyo CheolKwak, Chun Sik
Department
Dept. of Pathology (병리학)
Dept. of Biochemistry (생화학)
Journal Title
Journal of Korean Medical Science
Issued Date
1996
Volume
11
Issue
3
Keyword
AllopurinolCholestasisOxygen free radicalsXanthine oxidase
Abstract
To determine whether oxygen free radicals are responsible for the pathogenesis of the cholestasis induced by ligation of common bile duct (CBD) variables which reflect the hepatic function in the serum, the amount of superoxide radical production, and xanthine oxidase(XO) activity were studied. The activity of serum alanine aminotransferase, bilirubin level in the serum and the amount of superoxide radical production were lower in a CBD ligation with allopurinol treated group than in a CBD ligation without allopurinol treated group. Abnormalities of the microscopic structures were reduced in a CBD ligation with allopurinol treated group than in a CBD ligation without allopurinol treated group. Allopurinol, an inhibitor of XO, prevented the hepatic damage induced by CBD ligation through the inhibition of XO. These experiments demonstrate that oxygen free radicals are responsible for the pathogenesis of the cholestatic liver.
Keimyung Author(s)(Kor)
권건영
문교철
곽춘식
Publisher
School of Medicine
Citation
Kyo-Cheol Mun et al. (1996). The Protective Effect of Allopurinol on Cholestatic Liver Injury Induced by Bile Duct Ligation. Journal of Korean Medical Science, 11(3), 239–243. doi: 10.3346/jkms.1996.11.3.239
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.1996.11.3.239
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33818
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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