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Subpopulations of Regulatory T Cells in Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Behcet’s Disease

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Author(s)
Jae-Ryong KimJin-Nyeong ChaeSang-Hyon KimJung-Sook Ha
Keimyung Author(s)
Kim, Jae RyongHa, Jung SookKim, Sang Hyon
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2012
Volume
27
Issue
9
Keyword
Regulatory T CellsAutoimmune DiseasesSystemic Lupus ErythematosusRheumatoid ArthritisBehcet Disease
Abstract
Recently, subpopulations of regulatory T (Treg) cells, resting Treg (rTreg) and activated Treg
(aTreg), have been discovered. The authors investigated the relationship between the
change of Treg, aTreg and rTreg and autoimmune diseases. Treg cells and those
subpopulations were analyzed by using the human regulatory T cell staining kit and
CD45RA surface marker for 42 rheumatoid arthritis (RA), 13 systemic lupus sclerosis (SLE),
7 Behcet’s disease (BD), and 22 healthy controls. The proportion of Treg cells was
significantly lower in RA (3.8% ± 1.0%) (P < 0.001) and BD (3.3% ± 0.5%) (P < 0.01)
compared to healthy controls (5.0% ± 1.3%). The proportion of aTreg cells was also
significantly lower in RA (0.4% ± 0.2%) (P = 0.008) and BD (0.3% ± 0.1%) (P = 0.013)
compared to healthy controls (0.6% ± 0.3%). The rTreg cells showed no significant
differences. The ratio of aTreg to rTreg was lower in RA patients (0.4% ± 0.2%) than that
in healthy controls (0.7% ± 0.4%) (P = 0.002). This study suggests that the decrement of
aTreg not rTreg cells contributes the decrement of total Treg cells in peripheral blood of RA
and BD autoimmune diseases. Detailed analysis of Treg subpopulations would be more
informative than total Treg cells in investigating mechanism of autoimmune disease.
Keimyung Author(s)(Kor)
김재룡
하정숙
김상현
Publisher
School of Medicine
Citation
Jae-Ryong Kim et al. (2012). Subpopulations of Regulatory T Cells in Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Behcet’s Disease. Journal of Korean Medical Science, 27(9), 1009–1013. doi: 10.3346/jkms.2012.27.9.1009
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2012.27.9.1009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33819
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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