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Human Papillomavirus Infection in Lung and Esophageal Cancers: Analysis of 485 Asian Cases

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Author(s)
Akiteru GotoChih-Ping LiSatoshi OtaToshiro NikiYuji OhtsukiShinichi KitajimaSuguru YonezawaChihaya KoriyamaSuminori AkibaHisataka UchimaYueh-Min LinKun-Tu YehJae-Soo KohChul-Woo KimKun-Yong KwonMin En NgaMasashi Fukayama
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Medical Virology
Issued Date
2011
Volume
83
Issue
8
Keyword
human papillomavirus (HPV)Asiageographical distributionlung canceresophageal cancer
Abstract
The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV.
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Akiteru Goto et al. (2011). Human Papillomavirus Infection in Lung and Esophageal Cancers: Analysis of 485 Asian Cases. Journal of Medical Virology, 83(8), 1383–1390. doi: 10.1002/jmv.22150
Type
Article
ISSN
0146-6615
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.22150
DOI
10.1002/jmv.22150
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33828
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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