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Protective Effect of Propofol Against Kainic Acid–Induced Lipid Peroxidation in Mouse Brain Homogenates Comparison with Trolox and Melatonin

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Author(s)
Hyung LeeYoung-Ho JangSeong-Ryong Lee
Keimyung Author(s)
Lee, HyungLee, Seong RyongJang, Young Ho
Department
Dept. of Neurology (신경과학)
Dept. of Pharmacology (약리학)
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Neurosurgical Anesthesiology
Issued Date
2005
Volume
17
Issue
3
Keyword
propofolantioxidantkainic acidlipid peroxidation
Abstract
This study compared the effectiveness of propofol with
that of trolox and melatonin for reduction of lipid peroxidation
in vitro. Lipid peroxidation was induced by addition of kainic acid
(KA; 10 mM), hydrogen peroxide (H2O2; 10 mM), or ferrous ammonium
sulfate (5 mM) to mouse brain homogenate, and thiobarbituric
acid–reactive substances (TBA-RS) were used as a marker of
lipid peroxidation. Propofol, trolox, and melatonin reduced KA-,
H2O2-, and ferrous ammonium sulfate–induced lipid peroxidation
in a concentration-dependent manner. In reducing KA-induced lipid
peroxidation, 50% inhibitory concentration (IC50) values of antioxidants
were as follows: propofol (11.33 mM), trolox (4.00 mM),
and melatonin (9.72 mM). In reducing H2O2-induced lipid peroxidation,
IC50 values of antioxidants were as follows: propofol
(56.86 mM), trolox (33.34 mM), and melatonin (26.63 mM). In reducing
ferrous ion–induced lipid peroxidation, IC50 values of antioxidants
were as follows: propofol (49.57 mM), trolox (60.35 mM),
and melatonin (22.02 mM). Under the in vitro conditions of this
experiment, propofol was an excellent and a very potent antioxidant
in inhibiting KA-, H2O2-, and ferrous ion–induced lipid peroxidation
in mouse brain homogenates. We conclude that the antioxidant
properties of propofol at clinically relevant anesthetic concentrations
may have a neuroprotective effect.
Keimyung Author(s)(Kor)
이형
이성용
장영호
Publisher
School of Medicine
Citation
Hyung Lee et al. (2005). Protective Effect of Propofol Against Kainic Acid–Induced Lipid Peroxidation in Mouse Brain Homogenates Comparison with Trolox and Melatonin. Journal of Neurosurgical Anesthesiology, 17(3), 144–148.
Type
Article
ISSN
0898-4921
Source
http://insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=16037735
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33845
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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