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Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina

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Author(s)
Cheol Whan LeeIlseon HwangChan-Sik ParkHyangsin LeeDuk-Woo ParkSu-Jin KangSeung-Whan LeeYoung-Hak KimSeong-Wook ParkSeung-Jung Park
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Thrombosis and Thrombolysis
Issued Date
2012
Volume
33
Issue
4
Keyword
ADAMTS proteaseCoronary diseasePlaque stability
Abstract
ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) proteases are emerging as key participants in the pathogenesis of vascular diseases. We studied the expression of ADAMTS-2, -3, -4 and -14 in the culprit plaques from patients presenting with acute myocardial infarction (AMI) versus stable angina. Tissue samples were gathered from 52 patients with AMI (n = 35) or stable angina (n = 17) who underwent directional coronary atherectomy. The specimens were stained with hematoxylin-eosin and analyzed immunohistochemically using antibodies specific to ADAMTS-2, -3, -13 and -14, and markers for endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics of the groups were mostly similar. The proportion of smooth muscle α-actin-immunopositive area was smaller in the AMI group than in the stable angina group, but the areas immunopositive for CD31 or CD68 were higher in the AMI group. The relative areas immunopositive for ADAMTS-2, -3, and -13 in AMI were significantly larger than those in stable angina. However, the proportion of areas immunopositive for ADAMTS-14 did not differ between the two groups. Areas that stained for ADAMTS-2, -3, -13, and -14 largely overlapped with those positive for CD31 or CD68. The areas immunopositive for ADAMTS proteases were significantly correlated with CD31- or CD68-immunostained areas. In conclusions, ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. These results support a role for these enzymes in the pathogenesis of AMI.
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine
Citation
Cheol Whan Lee et al. (2012). Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina. Journal of Thrombosis and Thrombolysis, 33(4), 362–370. doi: 10.1007/s11239-011-0673-7
Type
Article
ISSN
0929-5305
Source
https://link.springer.com/article/10.1007%2Fs11239-011-0673-7
DOI
10.1007/s11239-011-0673-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33890
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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