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Unrestricted Use of 2 New-Generation Drug-Eluting Stents in Patients With Acute Myocardial Infarction A Propensity Score-Matched Analysis

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Author(s)
Kang-Yin ChenSeung-Woon RhaLin WangYong-Jian LiGuang-Ping LiKanhaiya L. PoddarJi-Young ParkCheol Ung ChoiChang-Gyu ParkHong Seog SeoDong Joo OhMyung Ho JeongYoung Keun AhnTaek Jong HongYoung Jo KimSeung Ho HurIn Whan SeongJei Keon ChaeMyeong Chan ChoJang Ho BaeDong Hoon ChoiYang Soo JangIn Ho ChaeChong Jin KimJung Han YoonWook Sung ChungKi Bae SeungSeung Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
JACC: Cardiovascular Interventions
Issued Date
2012
Volume
5
Issue
9
Keyword
acute myocardial infarctioneverolimus-eluting stentspercutaneous coronary interventionzotarolimus-eluting stents
Abstract
Objectives:

This study sought to compare everolimus-eluting stents (EES) with zotarolimus-eluting stents (ZES) in patients with acute myocardial infarction (AMI).


Background:

There is a paucity of data to exclusively evaluate the safety and efficacy of second-generation drug-eluting stents (DES) in the setting of AMI.


Methods:

The present study enrolled 3,309 AMI patients treated with ZES (n = 1,608) or EES (n = 1,701) in a large-scale, prospective, multicenter registry—KAMIR (Korea Acute Myocardial Infarction Registry). Propensity score matching was applied to adjust for differences in baseline clinical and angiographic characteristics, producing a total of 2,646 patients (1,343 receiving ZES, and 1,343 receiving EES). Target lesion failure (TLF) was defined as the composite of cardiac death, recurrent nonfatal myocardial infarction, or target lesion revascularization. Major clinical outcomes at 1 year were compared between the 2 propensity score-matched groups.


Results:

After propensity score matching, baseline clinical and angiographic characteristics were similar between the 2 groups. Clinical outcomes of the propensity score-matched patients showed that, despite similar incidences of recurrent nonfatal myocardial infarction and in-hospital and 1-year mortality, patients in the EES group had significantly lower rates of TLF (6.5% vs. 8.7%, p = 0.029) and probable or definite stent thrombosis (0.3% vs. 1.6%, p < 0.001), compared with those in the ZES group. Furthermore, there was a numerically lower rate of target lesion revascularization (1.2% vs. 2.2%, p = 0.051) in the EES group than in the ZES group.


Conclusions:

In this propensity-matched comparison, EES seems to be superior to ZES in reducing TLF and stent thrombosis in patients with AMI.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Kang-Yin Chen et al. (2012). Unrestricted Use of 2 New-Generation Drug-Eluting Stents in Patients With Acute Myocardial Infarction A Propensity Score-Matched Analysis. JACC: Cardiovascular Interventions, 5(9), 936–945. doi: 10.1016/j.jcin.2012.05.009
Type
Article
ISSN
1936-8798
DOI
10.1016/j.jcin.2012.05.009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33908
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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